(A) Bio-imaging analysis to evaluate the therapeutic effect of iPS-ML producing IFN-β on metastatic liver cancer. (B) Quantification of the image data shown in A. (C) Histological data indicating migration of iPS-ML (PKH26, red) into …more Causes of the most common form of liver cancer, hepatocellular carcinoma (HCC), include hepatitis B or C, cirrhosis, obesity,...
Tag: <span>Stem Cells</span>
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Just ONE injection of stem cells from a man’s stomach could be a permanent cure for impotence (and even help them to lose weight)
Trial results show the therapy effectively restores spontaneous sexual function Each man had a small sample of fat taken from their stomach using liposuction Findings could pave the way for treatment for men who don’t respond to Viagra The approach would be particularly valuable for men made impotent by surgery A single injection of stem...
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From skin to brain: Stem cells without genetic modification
The top four images, from left to right, show Keratinocyte-derived neural crest stem cells turning into neurons as shown by typical neuronal morphology. The larger image, directly above, is a close-up of the far right image. UB study yields neural crest cells from adult skin cells, and could lead to new treatments for Parkinson’s and...
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Researchers decipher how the body controls stem cells
Stem cells are unspecialized cells that can develop into any type of cell in the human body. So far, however, scientists only partially understand how the body controls the fate of these all-rounders, and what factors decide whether a stem cell will differentiate, for example, into a blood, liver or nerve cell. Researchers from the...
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The intestine has a reservoir of stem cells that are resistant to chemotherapy
These comprise a small group of passive stem cells -quiescent- that are activated when needed and have the capacity to produce any kind of intestinal cell. Quiescent cells are relevant for tissue regeneration and for participation in tumor development After Chemotherapy, these cells change their behaviour, become active and regenerate all cell types in the...
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Stem cells make potential drug side effects personal
Researchers in Singapore have developed a way to use patients’ stem cells to see whether a cancer drug is safe for them In a promising development that strengthens the case for personalized cancer care, scientists in Singapore have demonstrated the possibility of predicting the potential for an individual to have adverse side effects to different drugs by first...
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Nanofiber matrix sends stem cells sprawling in all directions
Human stem cells grown on Kyoto University’s “fiber-on-fiber” culturing system Mighty promising as they are, stem cells certainly aren’t easy to come by. Recent scientific advances have however given their production a much-needed boost, with a Nobel-prize winning technology that turns skin cells into embryonic-like stem cells and another that promises salamander-like regenerative abilities being just a couple...
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The back-up mechanism that could stop you having a HEART ATTACK: Experts reveal a DIY repair process that causes the heart to grow new, healthy blood vessels
Why are some patients with heart disease less likely to die from it than others? Scientists believe the answer may partly lie in the body’s own repair mechanisms When blood flow to the heart is reduced, it starts to grow collateral blood vessels Why is it that some patients with heart disease are less likely...
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Improving longevity of functionally integrated stem cells in regenerative vision therapy
Image showing transplanted GFP-expressing human stem cell derived photoreceptors integrated in a host rodent retina stained for Otx2 in red. Stem cell therapies hold great promise for restoring function in a variety of degenerative conditions, but one of the logistical hurdles is how to ensure the cells survive in the body long enough to work....
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CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells
Highlights DNA end resection mechanism is hyper-activated during reprogramming CtIP protein levels increase during mouse and human cell reprogramming Loss of CtIP impairs mouse and human reprogramming efficiency Reprogramming without CtIP causes defects in iPSC self-renewal and differentiation Summary Acquired genomic instability is one of the major concerns for the clinical use of induced pluripotent...