by Charlene N. Rivera-Bonet, University of Wisconsin-Madison Specification of dorsal hindbrain (r1) neuroepithelia. a, Schematic representation of LC location along the embryonic forebrain, midbrain and hindbrain and their corresponding homeodomain transcription factors. b, Experimental design to pattern hindbrain r1 region from hPSCs during the first 6 d of neural induction. c, Expression of forebrain, midbrain and hindbrain...
by City University of Hong Kong The transplanted SOX9-suppressed neural stem cells (bottom) at injured site generated robust axons extending into the host spinal cord after 3 months post-graft. Credit: Advanced Science (2023). DOI: 10.1002/advs.202205804 A research team co-led by City University of Hong Kong (CityU) and The University of Hong Kong (HKU) has recently made a significant...
by Nara Institute of Science and Technology The gastric corpus, which is a major component of the glandular stomach, is composed of parietal, chief, pit, and neck cells. Each of these specialized epithelial cells play an important role in digestion, and they are continuously replenished by new ones which are formed via the differentiation of...
by Cell Press Credit: Unsplash/CC0 Public Domain Researchers have successfully converted human pluripotent stem cells into purified pituitary cells that aggregated into hormone-secreting organoids. As reported June 8 in the journal Stem Cell Reports, transplantation of these 3D pituitaries into mice with hypopituitarism resulted in long-lasting improvement in levels of adrenocorticotropic hormone (ACTH), which is normally...
by Jim Dryden, Washington University School of Medicine in St. Louis Using single-cell sequencing technology, diabetes researchers at Washington University School of Medicine in St. Louis have learned why islet beta cells produced from stem cells may not be as good at making insulin in response to blood sugar. The findings could improve treatment for those...
by Cedars-Sinai Medical Center Credit: CC0 Public Domain A new study led by Cedars-Sinai and the University of California, San Francisco (UCSF), has determined that altering a cellular process can lead stem cells—cells from which other cells in the body develop—to die or regenerate. The findings, published in the journal Cell Stem Cell, may assist in the...
By CHRISTOPHER CARBONE, U.S. SCIENCE AND TECHNOLOGY EDITOR FOR DAILYMAIL.COM Scientists have figured out a way to create eye tissue using stem cells and 3D printing – in new research that could lead to breakthroughs in treating a range of degenerative eye diseases. A team of researchers from the National Eye Institute (NEI), part of the National Institutes of...
by UT Southwestern Medical Center Graphical abstract. Credit: Cell Stem Cell (2022). DOI: 10.1016/j.stem.2022.10.002 New research from Children’s Medical Center Research Institute at UT Southwestern (CRI) found that different skeletal stem cell (SSC) populations contribute to repair of different kinds of bone injuries. In the study, published in Cell Stem Cell, researchers identified distinct cell markers that allowed...
The finding suggests possible targets for new cancer therapies. Stem cells’ ability to become other cell types is crucial to our bodies, both during development and throughout life. But this potential can be our downfall if it goes wrong, turning some of our most useful cells into malignant cancers. While investigating a pathway involved in...
by Rebekah McBride, University of Wisconsin-Madison Credit: CC0 Public Domain Lab-grown human heart cells provide a powerful tool to understand and potentially treat heart disease. However, the methods to produce human heart cells from pluripotent stem cells are not optimal. Fortunately, a new study out of the University of Wisconsin–Madison Stem Cell & Regenerative Medicine...
