by Zhang Nannan, Chinese Academy of Sciences Schematic illustration of the mechanism of Oct4A palmitoylation promotes tumorigenicity and stemness in human glioblastoma cells. Credit: Chen Xueran Researchers led by Prof. Fang Zhiyou and Prof. Chen Xueran from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences (CAS), have found, for the first...
By Michael Irving May 08, 2022 Mesenchymal stem cells have shown promise in tests in mice for preventing type 1 diabetes developing as a side effect of cancer immunotherapy Depositphotos Type 1 diabetes can be a rare but serious side effect of a cancer treatment that use what are known as immune checkpoint inhibitors. In...
Human induced pluripotent stem cells (hiPSCs) hold great promise for treating many currently untreatable diseases. Scientists can turn them into brain, liver, heart and other types of cells that could mend injured or unhealthy ones. However, the processes for culturing and differentiating hiPSCs into other kinds of cells take a lot of time and resources,...
by University of Helsinki Beta cells (green) produce the hormone insulin. Credit: Masur / Wikimedia Commons Insulin is a vital hormone produced by pancreatic beta cells. Type 1 diabetes is caused by the destruction of these cells, which results in patients having to replace the lost insulin with multiple daily injections. Insulin secretion can be...
BOSTON CHILDREN’S HOSPITAL IMAGE: DERIVED FROM PATIENTS’ CELLS, A NEW AIRWAY MODEL CONTAINING CILIATED RESPIRATORY ENDOTHELIAL CELLS RECAPITULATES SARS-COV-2 INFECTION AND CAN BE USED TO TEST DRUGS. THREE CILIATED CELLS IN THIS MODEL ARE INFECTED WITH THE VIRUS. CREDIT: CHANTELLE SIMONE ROACH, BOSTON CHILDREN’S, AND JAKE LA SUER, BOSTON UNIVERSITY. What happens in our respiratory...
JOHNS HOPKINS MEDICINE IMAGE: UNLIKE MOST OTHER CELLS, MANNOSE RESIDUES (GREEN) ARE ABUNDANT ON THE MSC CELL MEMBRANE. USING AN MRI TECHNIQUE THAT IS SENSITIVE TO THE PRESENCE OF MANNOSE, TRACKING OF TRANSPLANTED MSCS IS NOW POSSIBLE WITHOUT THE NEED OF LABELING THEM. CREDIT: IMAGE COURTESY OF SHREYAS KUDDANNAYA EMBARGOED TILL MONDAY, FEB. 7 AT...
Diabetes researchers are reporting early success in a first-in-humans clinical trial to test whether pancreatic cells grown from stem cells can be safely implanted and begin to produce insulin. The team reported on their proof of concept and safety study in a newly published paper in the journal Cell Reports Medicine. Of 17 patients who received implants, 35 percent...
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR), SINGAPORE IMAGE: AN INVASIVE GASTRIC TUMOUR CONTAINING LGR5-EXPRESSING STEM-LIKE CELLS (GREEN), SOME OF WHICH ARE ACTIVELY PROLIFERATING (MAGENTA). ELIMINATION OF THESE TUMOUR-RESIDENT LGR5-EXPRESSING POPULATIONS GREATLY REDUCES TUMOUR GROWTH AND SPREAD IN MICE. CREDIT: SOWMYA SAGIRAJU AND GRACE LIM, INSTITUTE OF MOLECULAR AND CELL BIOLOGY (IMCB), A*STAR SINGAPORE – Scientists...
by Kyoto University The Hidetoshi Sakurai laboratory shows how iPS cells can replenish collagen VI to regenerate muscles in mice suffering from Ullrich congenital muscular dystrophy. Credit: Kyoto University Muscle dystrophy describes a set of diseases that causes the weakening and loss of muscle. Ullrich congenital muscular dystrophy is a rare disease that is the...
NOVEMBER 23RD, 2021 CONN HASTINGS GENETICS, MEDICINE, ORTHOPEDIC SURGERY, PATHOLOGY, RADIOLOGY, SURGERY Scientists at Johns Hopkins used a combination of molecular labeling and imaging techniques to create a three-dimensional map of the blood vessels in the mouse skull. Their approach also reveals niches where stem cell populations lurk, which could help researchers to understand how...
