MIT biologists show that enlargement of blood stem cells restricts their ability to generate new blood cells during aging. MIT biologists have answered an important biological question: Why do cells control their size? Jette Lengefeld, a former postdoc in the lab of MIT Professor Angelika Amon. Image credits: Raleigh McElvery and Sebastian Swanson, MIT Cells of...
by Kyoto University Graphical abstract. Credit: DOI: 10.1016/j.ymthe.2021.05.016 Cancer therapies have seen great development over the decades. Radiotherapies and chemotherapies have saved countless lives, but the latest arsenal, adoptive cell therapies (ACT), has stirred most excitement. In ACT, cells are processed to enhance their anti-cancer immune effects and injected into the patient. A new study by...
A new approach to repairing peripheral nerves marries the regenerating power of gingiva-derived mesenchymal stem cells with a biological scaffold to enable the functional recovery of nerves following a facial injury, according to a study by a cross-disciplinary team from the University of Pennsylvania School of Dental Medicine and Perelman School of Medicine. Faced with...
by University of Southampton Credit: CC0 Public Domain Researchers at the University of Southampton have invented a new way to generate human cartilage tissue from stem cells. The technique could pave the way for the development of a much-needed new treatment for people with cartilage damage. Cartilage acts as a shock absorber in joints, but it is susceptible to...
by Max Planck Society Stained calcium (dark brown) in stem cells from the bone marrow: Young stem cells (left) produce more material for bone than old stem cells (center). They can be rejuvenated by adding sodium acetate (right). Credit: Pouikli/Max Planck Institute for Biology of Ageing As we age, our bones become thinner, we suffer fractures...
Researchers have found that old skeletal stem cells contribute to bone fragility and poor healing in mice, but that a stem cell-boosting gel may help restore function. Stanford Medicine researchers have discovered how genetic and molecular changes in aging skeletal stem cells may contribute to poor fracture healing, osteoporosis and various blood disorders, as well as general inflammation...
by Kyoto University Engrafted iPSC-tenocytes express tendon functional extracellular matrix at two weeks after transplantation. a Histological analyses of iPSC-tenocytes rats, untreated rats, and uninjured rats at 4 weeks after transplantation. Masson’s trichrome staining shows collagen fiber (blue), cytoplasm (red), and nuclei (purple). Representative pictures of the transplanted area (left Achilles tendon) are shown. The boxed...
IMAGE: MESENCHYMAL STROMAL CELLS (MSCS) ARE POTENT IMMUNOMODULATORS THAT HAVE SHOWN PROMISE IN TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD). USING TRANSCRIPTOMICS, RESEARCHERS HAVE DEMONSTRATED THAT MSC INFUSIONS ELICIT A STRONG, YET TRANSIENT (<7 DAYS) TRANSCRIPTIONAL RESPONSE IN CIRCULATING MONONUCLEAR CELLS OF COPD PATIENTS, ATTENUATING KEY PRO-INFLAMMATORY PATHWAYS. THESE RESPONSES ARE LIKELY MEDIATED BY SOLUBLE FACTORS...
by University of Oxford Credit: Unsplash/CC0 Public Domain High levels of glucose in the blood “reprogrames” stem cells, leading to a lasting increase in the risk of developing dangerous atherosclerosis, according to research funded by the British Heart Foundation published today in Circulation. University of Oxford researchers found that high blood glucose, a hallmark of diabetes, alters stem cells...
by University of California, Irvine “Our study can transform our understanding of how transplanted stem cells actually work in the body to treat disease,” says Weian Zhao, UCI professor of pharmaceutical sciences. He and graduate student researcher Zachary Wagoner are co-authors of a commentary published online in Nature Biomedical Engineering. Credit: School of Pharmacy & Pharmaceutical Sciences...
