A glue ingredient was the secret to getting the mouse cellsto multiply outside the body. Researchers have managed to grow large numbers of blood-forming stem cells in the lab using a surprisingly simple ingredient found in glue. And when injected into mice, the cells started producing key components of blood. “The finding is very unexpected and...
Tag: <span>stemcell</span>
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Using Antibodies to Detect the Expression of Neural Stem Cell Markers
by Atlas Antibodies Neural Stem Cells Collectively, markers against neural stem cells (NSCs) represent a robust tool in basic research and advanced regenerative medicine. Studies focused on differentiation toward specific neural lineages are supported by changes in the expression levels of specific markers, which can help to identify the presence of neural stem cells. Nestin and SOX2 are two commonly utilized markers for NSCs. Other markers expressed at the cellsurface are ABCG2, FGFR1 and Frizzled-9. NSCs differentiate into...
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Scientists discover self-defense “switch” for stem cells
With the power to turn themselves into any other cell in the body, stem cells have a future as a key treatment for a range of diseases and injuries. The problem is, they lack some of the self-defense mechanisms that other cells have, leaving them open to attack from viruses and other threats. Now, researchers...
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Pluripotency or differentiation — That is the question
HELMHOLTZ ZENTRUM MÜNCHEN – GERMAN RESEARCH CENTER FOR ENVIRONMENTAL HEALTH Induced pluripotent stem cells can turn into any type of cell in the body or remain in their original form. In the current edition of Molecular Cell, scientists from the Helmholtz Zentrum München describe how cells “decide” which of these two directions to take. During their research, they...
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Using stem cells to combat osteoarthritis
Published Today By Tim Newman Fact checked by Isabel Godfrey In a recent preliminary study, scientists used stem cells to ease osteoarthritis. Although the trial was small-scale, the results are promising and will pave the way for larger studies. Osteoarthritis of the knee (KOA) occurs when the cartilage — the joint’s natural cushioning system —...
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UC San Diego Health treats first cancer patient with stem-cell derived natural killer cells
After 10 years in remission, Derek Ruff’s cancer returned, this time as stage IV colon cancer. Despite aggressive rounds of chemotherapy, palliative radiotherapy and immunotherapy, his disease progressed. In February 2019, as part of a phase I clinical trial at Moores Cancer Center at UC San Diego Health, Ruff became the first patient in the world to be treated for cancer with a human-induced pluripotent stem cell (iPSC)-derived cell therapy called FT500. “This is...
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Biologists find a way to boost intestinal stem cell populations
Study suggests that stimulating stem cells may protect the gastrointestinal tract from age-related disease. MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA — Cells that line the intestinal tract are replaced every few days, a high rate of turnover that relies on a healthy population of intestinal stem cells. MIT and University of Tokyo biologists have now...
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Targeting stem-like cells could prevent ovarian cancer recurrence
Ovarian cancer is not the most common form of cancer, but it’s among the deadliest. That’s because about 70 percent of cases recur. A new study by researchers at the University of Pittsburgh, UPMC Hillman Cancer Center, Magee-Womens Research Institute (MWRI) and several other collaborating institutions targets the root of recurrence with new drugs aimed...
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Diabetes impairs multipotent stromal cell antibacterial activity
New Rochelle, NY, March 4, 2019-A new study reveals that the multipotent stromal cells (MSCs) of persons with diabetes have diminished capacity to fight off bacterial infection, providing new understanding into the basis of diabetes-associated immune dysfunction. The research is published in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers....
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UTMB develops drug to rejuvenate muscle cells
Elderly to feel fitter, faster and stronger UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON GALVESTON, Texas – Researchers from The University of Texas Medical Branch at Galveston have developed a promising drug that has proven to significantly increase muscle size, strength and metabolic state in aged mice, according to a study just published in Biochemical...