Nocodazole can enrich cells in the G2/M, G1, and S phases of the cell cycle Treatment with nocodazole does not affect pluripotency maintenance hPSCs can efficiently form functional cell types after nocodazole treatment Nocodazole treatment allows genome-wide analyses of synchronous populations Summary Cell cycle progression and cell fate decisions are closely linked in human pluripotent stem cells (hPSCs). However, the study of these...
Tag: <span>stemcell</span>
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Stem cell shots linked to bacterial infection outbreak
Health officials on Thursday reported an outbreak of bacterial infections in people who got injections of stems cells derived from umbilical cord blood. In this Oct. 22, 2008 file photo, a researcher examines human embryonic stem cells with a microscope in Michigan. On Thursday, Dec. 20, 2018, the Centers for Disease Control and Prevention reported that at...
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Maintaining the unlimited potential of stem cells
Salk scientists discover new protein complex that keeps embryonic stem cells at stage of fullest potential, a key to regenerative medicine SALK INSTITUTE LA JOLLA–(December 11, 2018) Embryonic stem cells (ESCs) are the very definition of being full of potential, given that they can become any type of cell in the body. Once they start...
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New insight into stem cell behaviour highlights therapeutic target for cancer treatment
Research led by the University of Plymouth and Technische Universität Dresden has identified a new therapeutic target for cancer treatment and tissue regeneration – a protein called Prominin-1. Dr Bing Hu. Credit: University of Plymouth Dr. Bing Hu from Plymouth’s Institute of Translational and Stratified Medicine (ITSMed), together with Dr. Denis Corbeil from the Technische...
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Stem cell researchers develop promising technique to generate new muscle cells in lab
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON To help patients with muscle disorders, scientists at The University of Texas Health Science Center at Houston (UTHealth) have engineered a new stem cell line to study the conversion of stem cells into muscle. Findings appeared in Cell Reports. IMAGE: UTHEALTH STEM CELL RESEARCHERS, FROM THE LEFT, ARE NADINE MATTHIAS, DVM; JIANBO WU, PH.D.; RADBOD DARABI, M.D., PH.D.; AND...
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Are Stem Cells the Future of Effective Back Pain Treatment?
According to the National Institute of Neurological Disorders and Stroke, 80 percent of Americans will have at least one episode of lower (or lumbar) back pain in their lifetimes. Discomfort or pain in the cervical and thoracic regions is common as well, with an estimated third or so of Americans living with pain at any...
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Proposed cancer treatment may boost lung cancer stem cells, study warns
Study adds evidence that cancer stem cells drive adenocarcinoma; suggests new strategy that makes tumor cells less “stem-like” BOSTON CHILDREN’S HOSPITAL Epigenetic therapies — targeting enzymes that alter what genes are turned on or off in a cell — are of growing interest in the cancer field as a way of making a cancer less...
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Gene PPM1D gives stem cells a ‘winning boost’ after chemotherapy
Chemotherapy has been associated with an increased risk of leukemia years after the treatment, but what leads to that association is not clear. In this study published in the journal Cell Stem Cell, a team led by researchers at Baylor College of Medicine and MD Anderson Cancer Center combined clinical and laboratory studies to show...
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Stem cells control their own fate, making lab-grown tissues less effective
Understanding how stem cells interact with their surroundings could lead to better lab-grown tissues.Credit: Imperial College London Tissues grown in the lab from stem cells may fail to live up their therapeutic promise because the cells choose their own fate. For the last 20 years, scientists have worked to engineer tissues for use in a...
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The Rise of Direct Cell Reprogramming
There has been tremendous activity over the last decade in the development of stem cells therapeutics, which have relied on stem cell differentiation protocols, as well as techniques for direct cell reprogramming. Today, there are over 4,700 “stem cell” trials registered on ClinicalTrials.gov and publications have increased dramatically in recent years, demonstrating the rapidly growing interest of the scientific...