A team at the University of Toronto’s Medicine by Design has combined the latest genomic technology with machine learning in a new study that sheds light on brain stem cells, providing insights that could one day help the brain heal itself. “This research tells us more about how adult neural stem cells are formed in...
Tag: <span>stemcell</span>
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Clarification of how stem cells get activated to produce new hair
Summary: Stem cells residing in hair follicles are held in an inactive state for long periods of time. A new study shows that these quiescent periods are essential for maintaining the cells’ rejuvenating activity over time and clarifies the mechanisms that bring the cells in and out of quiescence. Adult stem cells serve as reservoir...
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Ability of stem cells expanded to regrow any tissue type
Summary: A new technique, which allows scientists to generate both embryonic and non-embryonic tissues from cultured stem cells, is a step toward growing donor organs and replacement tissues to combat aging and diseases. Stem cells can be totipotent or pluripotent meaning that these cells like embryo can develop into any type of tissue in the...
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From skin to brain: Stem cells without genetic modification
Summary: A discovery, several years in the making, demonstrates that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic modification, and that these stem cells can yield other cells that are present in the spinal cord and the brain. The applications could be significant, from studying...
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Study investigates how to turn stem cells into motor neurons
Stem cells can develop into many different types of cells, such as muscle cells, red blood cells, or neurons. Given their special regenerative ability, stem cells can be used to treat a wide range of diseases. A team of researchers uncovers new details involved in the process of turning stem cells into motor neurons. ...
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Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas
Highlights Sumoylation regulates CD44 and MMP14 expression in basal breast and colon cancer SUMO inhibition clears cancer stem cells, repressing invasiveness and tumor growth Anacardic acid functions as a SUMO inhibitor to repress cancer stem cells TFAP2A mediates anti-tumor effects of SUMO inhibition in breast and colon cancers Summary Many solid cancers have an expanded...
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Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors
Highlights iENPs can be converted from fibroblasts using hESC-ENP enriched factors iENPs exhibit cellular and molecular characteristics resembling hESC-ENPs iENPs induced by different TF combinations exhibit different neural propensity iENP and their neuronal derivatives recapitulated HD and AD phenotypes Summary Early human embryonic stem cell (hESC)-derived neural populations consist of various embryonic neural progenitors (ENPs)...
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Can deafness be cured using stem cells? Treatment that can allow people to hear again may be ready in 10 years
Stem cell treatment for deafness Researchers have grown healthy human ear hair cells using stem cells These could one day be used to replace faulty ear cells in deaf people Patients born deaf are currently treated with an artificial cochlear implant Scientists believe they are ‘on the brink’ of a cure for hereditary deafness using...