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Newly discovered mechanism explains heightened risk for suicidal behavior among some contraceptive users

by Netherlands Institute for Neuroscience Infographic—What explains the increased likelihood of suicide in some contraceptive pill users? Credit: Netherlands Institute for NeuroscienceThe use of oral contraception containing a synthetic form of progesterone (progestogen) may lead to an increased risk of suicidal behavior for women with depression and suicidal ideations. Researchers at the Netherlands Institute for Neuroscience...

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GLP-1 Agonists and Suicide Risk: What Action Should Be Taken?

Boris Hansel, MD, PhDDISCLOSURES September 20, 2023 A statement from the European Medicines Agency (EMA) about semaglutide and, more generally, glucagon-like peptide 1 (GLP-1) agonists recently caused a stir. Could these medicines lead to patients taking their own lives?Medical Authorities Alert The EMA published a press release in early July 2023 to announce that a review is...

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GLP-1 Agonists and Suicide Risk: What Action Should Be Taken?

Boris Hansel, MD, PhD A statement from the European Medicines Agency (EMA) about semaglutide and, more generally, glucagon-like peptide 1 (GLP-1) agonists recently caused a stir. Could these medicines lead to patients taking their own lives? Medical Authorities AlertThe EMA published a press release in early July 2023 to announce that a review is underway...

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European regulators investigating reports of suicide risk in patients taking Novo Nordisk meds for weight loss

Beth Snyder Bulik Senior Editor The European Medicines Agency is looking into suicidal and self-harm ideation in three weight loss patients who used Novo Nordisk’s semaglutide or liraglutide medicines. The case reports were flagged by member agency Icelandic Medicines Agency. The EMA’s safety committee, the Pharmacovigilance Risk Assessment Committee (PRAC), is now investigating. “The case...

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USPSTF recommendation on screening for depression and suicide risk in adults

JAMA NETWORK Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends screening for depression in the adult population, including pregnant and postpartum persons and older adults. The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for suicide risk in the adult population, including pregnant and postpartum...

Study links hormones, blood sugar, blood lipids, and BMI to the severity of major depressive disorder and suicide risk
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Study links hormones, blood sugar, blood lipids, and BMI to the severity of major depressive disorder and suicide risk

by Association of Basic Medical Sciences of FBIH Hypothalamus-pituitary-adrenal axis (HPA axis) dysfunction is one of the important biochemical changes in depression. The development of depression will lead to changes in the function of HPA axis. Credit: Bosnian Journal of Basic Medical Sciences (2022). DOI: 10.17305/bjbms.2021.6754 A study, published in the Bosnian Journal of Basic Medical Sciences, provides insights into...

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Does Folic Acid Have an Effect on Suicide Risk?

Author: Charles P. Vega, MD Clinical Context Suicide remains in the top 10 for overall causes of mortality in the United States, and healthcare professionals may exacerbate the risk for suicide through the medications they prescribe. A previous study by the authors of the current research examined medications that might affect the risk for suicide....

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FDA Requires Disclosure of Suicide Risk for Anti-baldness Drug

By Dan Levine June 14, 2022 (Reuters) – U.S. health regulators rejected a request to remove popular anti-baldness pill Propecia and its generic versions from the market, but for the first time required patient notification about reports of suicidal behavior in men taking the drug. The U.S. Food and Drug Administration has previously approved revised Propecia labels...

Computerized adaptive test may help assess suicide risk
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Computerized adaptive test may help assess suicide risk

(HealthDay)—The Computerized Adaptive Test Suicide Scale (CAT-SS) can enhance personalized screening and assessment of suicide risk severity among U.S. veterans, according to a study published online Jan. 21 in PLOS ONE. Lisa A. Brenner, Ph.D., from the Rocky Mountain Regional Veterans Affairs Medical Center in Aurora, Colorado, and colleagues validated CAT-SS among veterans who completed the...

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