by Kanazawa University Principle of new therapeutic treatment. Credit: Kanazawa University The RB1 tumor suppressor gene protein antagonizes uncontrolled growth of cancer by suppressing cell cycle progression but its function is repressed in most cancers. CDK4/6 represses this function by phosphorylating RB1. In contrast, drugs that inhibit CDK4/6 inhibit the phosphorylation of RB1 and restore the...
