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Using synthetic gene cir­cuits to better control the timing of immunotherapy

Reviewed by Emily Henderson, B.Sc. Dec 16 2022 In two separate studies, researchers demonstrate how synthetic biology can be used to tackle a difficult issue in cancer immunotherapy: the way immunotherapy-related approaches focused on short-term killing of tumor cells may fail to eradicate tumors because growth of tumors happens on longer timescales. Here, two research...

Winner-takes-all synthetic gene circuit process opens new pathways to disease treatment
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Winner-takes-all synthetic gene circuit process opens new pathways to disease treatment

by  Arizona State University Tian’s research reveals a novel winner-takes-all resource competition between synthetic gene circuits within one host cell. Credit: Xiaojun Tian/ASU. A new process for inserting synthetic gene circuits into host cells, developed by a team of bioengineers at Arizona State University, has broad implications for improving the effectiveness of a range of disease therapies. Synthetic...