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Uncovering the cause of regulatory T cell dysfunction in elderly-onset rheumatoid arthritis
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Uncovering the cause of regulatory T cell dysfunction in elderly-onset rheumatoid arthritis

August 30, 2024 by University of Tsukuba Graphical abstract. Credit: Clinical Immunology (2024). DOI: 10.1016/j.clim.2024.110337Researchers at Tsukuba University have discovered that the increase in regulatory T (Treg) cells, which typically suppress immune responses, does not adequately control elderly-onset rheumatoid arthritis. In the arthritic environment, Treg cells exhibit altered metabolic activity, reduced suppressive function, and increased...