by University of Oxford Local (top) and systemic (bottom) solicited reactions following prime and boost vaccinations at different dose regimens. Day 0, day of vaccination; P, post-vaccination observation period in the clinic. Fever was classified as mild (38.0 °C to <38.5 °C), moderate (38.5 °C to <39.0 °C) and severe (≥39.0 °C). Feverish was defined as a self-reported feeling of feverishness....