October 1, 2024 by University of Los Andes Experimental workflow of MitoT to native and CAR engineered T cells. Credit: Journal of Translational Medicine (2024). DOI: 10.1186/s12967-024-05627-4In a pioneering study that bridges the gap between science fiction and reality, researchers have unveiled an innovative method to enhance T and CAR-T cells—our body’s natural and engineered...
Tag: <span>t cells</span>
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Research suggests many people already have T cells with the power to fight avian flu
September 17, 2024 by La Jolla Institute for Immunology Credit: CC0 Public DomainResearch led by scientists at La Jolla Institute for Immunology (LJI) suggests that many people already have immune cells on “stand by” to fight the H5N1 virus, also known as highly pathogenic avian influenza. The H5N1 “bird flu” virus emerged in 2022 and...
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A distinct ‘repair’ role of regulatory T cells in fracture healing
August 30, 2024by Higher Education Press Credit: Tingting Wu, Lulu Wang, Chen Jian, Zhenhe Zhang, Ruiyin Zeng, Bobin Mi, Guohui Liu, Yu Zhang, Chen ShiA study in Frontiers of Medicine uncovers a unique reparative function of regulatory T cells (Tregs) in the process of fracture healing, a discovery that adds a new dimension to our...
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T cells and aging: Unraveling the complexities of lifespan
July 25, 2024 by Tsinghua University Press Linear differentiation characteristics of T cells in peripheral circulation and changes with aging. SCM: stem cell memory T cells; CM: central memory T cells; EM: effector memory T cells; EMRA: effector memory CD45RA T cells. Credit: Aging Research (2024). DOI: 10.26599/AGR.2024.9340021Aging significantly impacts the immune system, notably through...
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Serendipity reveals new method to fight cancer with T cells
JULY 2, 2024 by Laura Red Eagle, University of Wisconsin-Madison Graphical abstract. Credit: Molecular Therapy – Methods & Clinical Development (2024). DOI: 10.1016/j.omtm.2024.101249A promising therapy that treats blood cancers by harnessing the power of the immune system to target and destroy cancer cells could now treat solid tumors more efficiently. Thanks to a recent study...
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Scientists discover new T cells and genes related to immune disorders
by RIKEN A newly developed method called ReapTEC allowed the discovery of thouands of active bidirectional enhancers. Further anaylis of GWAS data revelaed that various immune-mediated diseases, like multipkle sclerosis and rheumatoisd arthritis, are related to genetic variations within these enhancers. Credit: RIKEN Researchers led by Yasuhiro Murakawa at the RIKEN Center for Integrative Medical...
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Review discusses metabolic reprogramming of T cells
by Cactus Communications T cell immunotherapy can be optimized by understanding the metabolism of T cells. This review article summarizes the intricacies of effector and memory T cell metabolic reprogramming and how metabolism can drive T cell exhaustion. Credit: Bo Huang from Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical CollegeWhen foreign antigens...
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T cells can be reprogrammed to fight aging
Cold Spring Harbor LaboratoryThe fountain of youth has eluded explorers for ages. It turns out the magic anti-aging elixir might have been inside us all along. Cold Spring Harbor Laboratory (CSHL) Assistant Professor Corina Amor Vegas and colleagues have discovered that T cells can be reprogrammed to fight aging, so to speak. Given the right...
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Dysfunction of mitochondria drives the exhaustion of T cells, study shows
by Julius-Maximilians-Universität Würzburg a Adoptive co-transfer of WT (tdTomato+GFP+) and HIF-1α-deficient (tdTomato+) P14 T cells into C57BL/6 mice before chronic infection with LCMV clone 13 (LCMVCL13). 21 days post infection (d.p.i.), donor P14 WT and HIF-1α-deficient T cells were FACS sorted, barcoded, and multiplexed in a 1:1 ratio and subjected to single-cell RNA sequencing. Uniform manifold...
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Bacteria Tag Team Tumors with T Cells
OCTOBER 31ST, 2023 CONN HASTINGS A team at Columbia University School of Engineering and Applied Science has developed a technique to enhance chimeric antigen receptor (CAR) T cell therapy in solid tumors. The technique involves engineering E. coli bacteria, that naturally tend to accumulate in the immune privileged core of solid tumors. The bacteria have...