by University of Michigan If cancer is a series of puzzles, a new study pieces together how several of those puzzles connect to form a bigger picture. One major piece is the immune system and the question of why certain immune cells stop doing their job. Another piece involves how histones are altered within immune...
Elucidation of the mechanism by which active oxygen induces cell death and inflammation THE INSTITUTE OF MEDICAL SCIENCE, THE UNIVERSITY OF TOKYO CELLS WERE TREATED WITH H2O2 FOR THE INDICATED TIMES. CELL EXTRACTS WERE ELECTROPHORESED UNDER NON-REDUCING CONDITIONS AND IMMUNOBLOTTED WITH AN ANTI-MYC ANTIBODY (TOP). IMMUNOPRECIPITATED MYC-MTK1 WAS ELECTROPHORESED UNDER REDUCING… view more CREDIT: ©TAKEKAWA...
by Children’s Hospital of Philadelphia A team of researchers from Children’s Hospital of Philadelphia (CHOP) used a new method of pinpointing potential disease-causing changes in the genome to identify two new potential therapeutic targets for lupus, while also paving the way for more accurately identifying disease-causing variations in other autoimmune disorders. The findings were published...
GERMAN CANCER RESEARCH CENTER (DEUTSCHES KREBSFORSCHUNGSZENTRUM, DKFZ) Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer of the blood and lymph system. This promising treatment comes at a cost, however: The manufacturers charge up to EUR 320,000 for the...
By Sara Ryding, B.Sc. Reviewed by Emily Henderson, B.Sc. Viral load refers to the amount of virus in an infected person’s blood. This is expressed as the number of viral particles in each milliliter of blood. Higher viral load can have different implications for different viruses but typically means the infection is progressing. Viral load...
GERMAN CANCER RESEARCH CENTER (DEUTSCHES KREBSFORSCHUNGSZENTRUM, DKFZ) PRINT E-MAIL In the fight against cancer or chronic infections, the immune system must be active over long periods of time. However, in the long run, the immune defence system often becomes exhausted. Scientists at the German Cancer Research Center (DKFZ) have now found initial evidence in mice...
This news or article is intended for readers with certain scientific or professional knowledge in the field. Like finding that needle in the haystack every time, your T cells manage what seems like an improbable task: quickly finding a few invaders among the many imposters in your body to trigger its immune response. T cells...
A mostly overlooked component of CAR-T cells has a surprisingly strong effect on the cancer-fighting cells’ behavior, scientists reported on Tuesday, including in ways that might affect their safety and efficacy. The component is called the co-stimulatory domain, and the two CAR-T therapies approved last year to treat forms of leukemia and lymphoma — Yescarta...
Killer T cells surround a cancer cell. While studying the underpinnings of multiple sclerosis, investigators at Brigham and Women’s Hospital came across important clues for how to treat a very different disease: cancer. In a paper published in Science Immunology, a group of researchers led by neurologist Howard Weiner, MD, describe an antibody that can...
