by Monash University Credit: CC0 Public Domain A collaborative study led by the Monash Biomedicine Discovery Institute (BDI) has discovered a new immune checkpoint that may be exploited for cancer therapy. The study shows that by inhibiting the protein tyrosine phosphatase PTP1B in T cells, the body’s immune response to cancer can be mobilized, helping to repress tumor...
by La Jolla Institute for Immunology Credit: CC0 Public Domain T cells play important roles in helping to fight infections and cancers—and they can also drive autoimmune diseases. Now researchers at La Jolla Institute for Immunology (LJI) have discovered new genes in CD4+ “helper” T cell subset that are linked to risk of autoimmune diseases....
by Monash University Alphonse Levaran’s drawings of malaria parasites invading red blood cells in the year 1880, now updated with new research showing that the immune system adapts to protect us from disease. Credit: Artwork created by Dr Erica Tandoori. Monash University’s Biomedicine Discovery Institute researchers have made a vital breakthrough in the understanding of a...
Patients with chronic rhinosinusitis sometimes suffer from the growth of polyps in the nasal cavity. These polyps are difficult to treat and often require surgical intervention. Even after removal by surgery, polyps can return and present a significant health burden for patients. White blood cells are known to release inflammatory signals that stimulate polyp growth....
by Technical University Munich Credit: CC0 Public Domain T cells play an important role in the human immune system. The blood cells classified as lymphocytes are formed in the bone marrow. From there they travel through blood vessels to the thymus gland in the breastbone. They then form receptors on their cellular surface to identify and...
by Delthia Ricks , Medical Xpress An artist’s depiction of a T cell. Credit: NIAID Just as it is for marathoners who’ve completed a 26-mile run, or shrubs that have gone without water in a heatwave—exhaustion is an unavoidable fact of life. Dogs get exhausted after herding sheep; birds turn in for the night after...
by Perelman School of Medicine at the University of Pennsylvania Credit: Pixabay/CC0 Public Domain Antibodies aren’t the only immune cells needed to fight off COVID-19—T cells are equally important and can step up to do the job when antibodies are depleted, suggests a new Penn Medicine study of blood cancer patients with COVID-19 published in Nature Medicine....
by Ludwig Maximilian University of Munich Credit: CC0 Public Domain In chronic infections, the immune system can become exhausted. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have looked into how this works. T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments—for instance, those derived from...
LA JOLLA INSTITUTE FOR IMMUNOLOGY IMAGE: TRANSMISSION ELECTRON MICROGRAPH OF SARS-COV-2 VIRUS PARTICLES, ISOLATED FROM A PATIENT. IMAGE CAPTURED AND COLOR-ENHANCED AT THE NIAID INTEGRATED RESEARCH FACILITY (IRF) IN FORT DETRICK, MARYLAND. CREDIT: NIAID LA JOLLA–A new study led by scientists at La Jolla Institute for Immunology (LJI) suggests that T cells try to fight...
by Forsyth Institute Dr. Carla Alvarez, a postdoctoral researcher at Forsyth and lead author of the paper. Credit: Matthew Modoono/Forsyth Institute In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don’t understand. What is the role of the immune response in the process? What happens...
