by UT Southwestern Medical Center The above illustration, in the center, shows activation of T cell immune response with the interaction of MHC-II (red) with the T cell receptor (TCR, blue), and also CD4 (light blue). CD4 and MHC-II are proteins expressed by T cells and antigen-presenting cells, respectively, to aid the recognition of antigens by...
CHILDREN’S NATIONAL HOSPITAL T-cells taken from the blood of people who recovered from a COVID-19 infection can be successfully multiplied in the lab and maintain the ability to effectively target proteins that are key to the virus’s function, according to a new study published Oct. 26 in Blood. “We found that many people who recover from COVID-19 have...
by University of Tsukuba Using the body’s immune system to fight cancer has great potential, but can also bring serious side effects, including itchy and painful skin reactions. But now, researchers from Japan have found how these skin reactions happen, potentially leading to a way to prevent them. In a study published this month in Communications Biology, researchers from the University...
by La Jolla Institute for Immunology Yellow staining shows CD*+T cells poised to target preproinsulin. The white outline on the right shows the perimeter of an insulin-containing islet in a patient with type 1 diabetes. The image shows that the preproinsulin-specific T cells can wait very close islets, probably poised to destroy the beta cells inside....
UNIVERSITY OF WÜRZBURG T cells play a key role in the human immune system. They are capable of distinguishing diseased or foreign tissue from the body’s own, healthy tissue with great accuracy; they are capable of triggering the actions necessary to fight off the troublemakers. The details of this immune response are manifold and the...
AMERICAN SOCIETY FOR MICROBIOLOGY WASHINGTON, D.C. – September 21, 2020 – Although people of any age can become infected with SARS-CoV-2, the virus that causes COVID-19, elderly patients face a higher risk of severity and death than younger patients. New research comparing the immune response among age groups, published this week in mBio, an open-access journal of the...
POHANG UNIVERSITY OF SCIENCE & TECHNOLOGY (POSTECH) INNATE T CELLS HAVE ANALOGOUS EFFECTOR SUBSETS. view more CREDIT: YOU JEONG LEE, SANGUK KIM (POSTECH) There are memory cells that remember previously encountered pathogens and help to react quickly and strongly when exposed to them again. The developmental process of strong immune cells that make these memory...
by Ana María Rodríguez, Ph.D., Baylor College of Medicine Scanning electron microscopy image of a human lymphocyte. Credit: National Cancer Institute Personalized cancer treatments are no longer just options of the future. In the past few years, researchers have made significant progress in ‘teaching’ the body’s immune T cells to recognize and kill specific cancer...
Antibody that blocks TREM2 protein frees immune cells to reject cancer WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IMMUNE CELLS INFILTRATE A HUMAN TUMOR IN THE FOUR COLORIZED IMAGES ABOVE. IN A MOUSE STUDY, RESEARCHERS AT WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST. LOUIS HAVE FOUND THAT AN… view more CREDIT: WILLIAM VERMI/MARTINA MOLGORA Immunotherapy has revolutionized...
AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE A treatment for multiple myeloma that harnesses the body’s cancer-fighting T cells was safe in humans and showed preliminary signs of effectiveness, according to a clinical trial involving 23 patients with relapsed or treatment-resistant disease. Although more research is needed to determine how well the treatment works, the...
