by RIKEN Scientists from the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine in Japan have used single-cell RNA analysis to find that supercentenarians—meaning people over the age of 110—have an excess of a type of immune cell called cytotoxic CD4 T-cells. Supercentenarians are a unique group of people. First,...
Tag: <span>T-cells</span>
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Creatine powers T cells’ fight against cancer
UNIVERSITY OF CALIFORNIA – LOS ANGELES HEALTH SCIENCES Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, serves as a molecular battery for immune cells by storing and distributing energy to power their fight against cancer, according to new UCLA research. The study, conducted in mice and published in...
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Immune cells reprogrammed to kill HIV-infected T cells
There exists a group of HIV-positive people who have the rare ability to naturally control the HIV infection. Now, after years of research, a team of scientists from the Institut Pasteur in Paris, has successfully reprogrammed cells that lack this ability, giving them the same incredible, antiviral potency. Less than one percent of people living...
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Scientists design protein that prods cancer-fighting T-cells
The new immunotherapy drug is designed to fight cancer while avoiding common side effects. This illustration depicts how the new protein, in red, binds only to the beta and gamma receptors, and not to cells with a third kind of receptor. (version with labels) Credit: Institute for Protein Design Scientists at UW Medicine’s Institute for...
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Newly identified T cells could play a role in cancer and other diseases
FINDINGS Researchers from the UCLA Jonsson Comprehensive Cancer Center and the La Jolla Institute for Immunology have identified a new type of T cell called a phospholipid-reactive T cell that is able to recognize phospholipids, the molecules that help form cells’ outer membranes. IMAGE: THIS IS UCLA CANCER RESEARCHER DR. RAM RAJ SINGH. CREDIT: COURTESY OF...
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T-cell biofactories find, fight disease in one fell swoop
NIBIB-funded researchers have transformed T cells into drug factories engineered to find cells carrying specific diseases in the body—and then produce therapeutic proteins localized to the diseased cells. Senior author Parijat Bhatnagar, Ph.D., director of cell-based medicine at the SRI International Center for Chemical Biology, Menlo Park, California, and his colleagues engineered the T-cell “biofactories”...
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Immune response mechanism described for fate determination of T cells
This knowledge can aid vaccine development, treatment of infections and moderation of autoimmune disease UNIVERSITY OF ALABAMA AT BIRMINGHAM BIRMINGHAM, Ala. – After a pathogen infects the body, the immune system responds with a remarkable — and remarkably complicated — cascade of events. IMAGE: THIS IS CASEY WEAVER. Some immune cells, called lymphocytes, migrate to the...
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A ‘homing system’ targets therapeutic T-cells to brain cancer
A multi-institution international team led by researchers at Baylor College of Medicine has developed a new strategy to overcome one of the main obstacles to the treatment of brain cancer—access to the tumor. Under the influence of cancer, the blood-brain barrier diverts immune T cells that attempt to enter the brain to fight the tumor....
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New anti-cancer drugs put cancers to sleep—permanently
In a world first, Melbourne scientists have discovered a new type of anti-cancer drug that can put cancer cells into a permanent sleep, without the harmful side-effects caused by conventional cancer therapies. Killer T cells surround a cancer cell. Credit: NIH Published today in the journal Nature, the research reveals the first class of anti-cancer drugs that work by putting...
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The immune system: T cells are built for speed
At TU Wien, immune cells are being examined using special microscopic methods, and this is causing previous ideas about the surface of T cells to be rethought. VIENNA UNIVERSITY OF TECHNOLOGY Without T cells, we could not survive. They are a key component of our immune system and have highly sensitive receptors on their surface...