by University of California, San Francisco Microglial cells. Credit: University of California, San Francisco (UCSF) Microglia are cells that are central to both brain health as well as disease progression in many neurological conditions. Normally, microglia stabilize the brain by clearing out damaged neurons and protein plaques often associated with dementia and other brain diseases. But...
by University of Montreal Numb is essential for long-term survival of RGCs. (A to L) Single-plane confocal images of retinal flat mounts stained for Brn3b from 5- (A to D), 8- (E to H), and 20-month-old (I to L) WT, Nbl KO, Numb+/−; Nbl KO, and cDKO mice, as indicated. Images were taken in the...
Tauopathies like Alzheimer’s disease are characterized by the spread of tau aggregates through the brain. Tau is one of the few molecules in the body that can become altered in a way that encourages other copies of the same molecule to also alter, causing aggregates to form. These aggregates and their surrounding biochemistry are disruptive to cell function...
