Highlights TIAM1 is part of the WNT-regulated destruction complex regulating TAZ/YAP stability WNT induces TIAM1 nuclear translocation where it reduces TAZ/YAP-TEAD interaction Nuclear TIAM1 blocks the TAZ/YAP genetic program inhibiting migration of CRC cells Nuclear TIAM1 predicts good prognosis in CRC Summary Aberrant WNT signaling drives colorectal cancer (CRC). Here, we identify TIAM1 as a...