by Mayo Clinic Human chromosomes (grey) capped by telomeres (white). Credit: PD-NASA; PD-USGOV-NASA In 2017, Cindy Sutherland caught a nasty cold she couldn’t shake. After coughing nonstop for weeks, she went to urgent care and got a chest X-ray. When the doctor shared the results with her, he asked, “Have you ever heard of pulmonary fibrosis?”...
Peer-Reviewed Publication IMPACT JOURNALS LLC IMAGE: FIGURE 2. COVID-19 PATIENTS PRESENT SHORTER TELOMERES IN THE ALVEOLAR TYPE II CELLS THAN CONTROLS. Here we reveal a link between short telomere length in ATII cells and post-viral lung fibrosis outcome in post-COVID-19 patients.” BUFFALO, NY- June 15, 2023 – A new research paper was published on the cover of Aging (listed...
Telomeres — the “caps” on the end of chromosomes that protect the DNA from damage — have been associated with greater longevity. In theory, longer telomeres should allow a cell to divide more times and therefore live longer. However, a new study has suggested that longer telomeres could increase a person’s risk of chronic health...
by Children’s Hospital of Philadelphia Representative images from subject 3 who had both measurable and MIBG-evaluable neuroblastoma and an overall central radiology reviewed PR from cycles 3 through 8, and PD at cycle 11. This patient enrolled with a history of progressive disease on a prior irinotecan-containing regimen. The left top panel shows the baseline 3.5-cm...
by University of North Carolina Health Care Newly discovered telomeric protein VR, (green spheres) is seen accumulating in nuclei (blue ovals) in human osteosarcoma cancer cells stained in red. Credit: Griffith Lab, UNC Lineberger Once thought incapable of encoding proteins due to their simple monotonous repetitions of DNA, tiny telomeres at the tips of our chromosomes...
SALK INSTITUTE IMAGE: TELOMERES PROTECT THE ENDS OF CHROMOSOMES FROM DAMAGE. THIS IMAGE SHOWS TELOMERES (GREEN) AND DNA (BLUE) DURING DNA REPAIR ACTIVITIES. CREDIT: SALK INSTITUTE LA JOLLA (February 8, 2023)—As we age, the end caps of our chromosomes, called telomeres, gradually shorten. Now, Salk scientists have discovered that when telomeres become very short, they...
by The Spanish National Cancer Research Centre Efficient Trf1 deletion in lung fibroblasts upon tamoxifen administration. a Generation of the conditional knockout mouse model in which Trf1 was deleted in fibroblasts using the Cre recombinase driven by the Col1a2 promoter. Trf1lox, KFPLox-LSL-Lox, and Col1a2-CreERT2 alleles are depicted before and after Cre-mediated excision. b Tamoxifen (TMX)...
By Michael Irving November 09, 2021 A new study suggests that telomeres, protective caps on the tips of chromosomes, might play a different role in aging than previously thoughtlightsource/Depositphotos Aging affects everybody, so it’s easy to understand why so much scientific attention is focused on studying it. Scientists in Canada now claim to have found...
Telomeres are caps of repeated DNA sequences at the ends of chromosomes. A little of the telomere length is lost with each cell division. A somatic cell with short telomeres ceases replication, and usually self-destructs. All cancers must thus continually lengthen telomeres in order to engage in unfettered replication and growth. This makes interference in telomere lengthening an attractive strategy as the basis for...
by Children’s Hospital Boston Capping decades of research, a new study may offer a breakthrough in treating dyskeratosis congenita and other so-called telomere diseases, in which cells age prematurely. Using cells donated by patients with the disease, researchers at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center identified several small molecules that appear to reverse...
