by National University of Singapore Identification and characterization of SWT-specific antibodies from convalescent patients in the early pandemic. a, Initial screening for SWT-specific antibodies from nine convalescent patients using ELISA. Of 771 antibodies produced in the culture supernatant, 476 (61.7%) had strong binding with optical density (OD) values above the cut-off of 0.2, more than...
by Alice McCarthy, Children’s Hospital Boston Credit: Unsplash/CC0 Public Domain A new method for producing antibodies against disease could result in a wider variety of drugs for infectious diseases, immune disease, and even cancer. The immune system naturally produces enormous varieties of antibodies to fight diseases. Therapeutic antibodies—antibodies created against specific therapeutic targets—have been used for decades to either rev...
by Duke-NUS Medical School As the current COVID-19 pandemic continues to adversely impact communities and economies across the world, efficiency in testing for the infection and antibodies is vital. A unique and rapid SARS-CoV-2 surrogate virus neutralization test (sVNT), developed in Singapore, may be the much-needed boost to current COVID-19 investigations to determine infection rate,...
by German Cancer Research Center A receptor in the cell layer that lines the blood vessels from the inside stimulates both the formation of new blood vessels in tumors and metastasis. Scientists at the German Cancer Research Center in Heidelberg (DKFZ) and the Mannheim Medical Faculty of the University of Heidelberg have succeeded in blocking...
by Brown University Researchers have discovered a promising new strategy for combating malaria, a mosquito-borne parasite that claims nearly a half-million lives each year. For a study reported in the journal Nature, researchers screened blood samples from children who had natural immune resistance to severe malaria infection. The study identified an antibody to a particular...
Findings have implications for treatment of a variety of fungal infections, including the main cause of meningitis UNIVERSITY OF MARYLAND As a world-renowned expert using intravital microscopy to observe fungal infection progression in live samples, Meiqing Shi, associate professor with the University of Maryland Department of Veterinary Medicine, continues to make new breakthroughs in the...
Using antibodies to treat disease has been one of the great success stories of early 21st-century medicine. Already five of the ten top-selling pharmaceuticals in the United States are antibody products. But antibodies are large, complex proteins that can be expensive to manufacture. Now, a team led by scientists from the Perelman School of Medicine...
