by Bar-Ilan University Credit: Pixabay/CC0 Public DomainSevere combined immunodeficiencies (SCIDs) are a group of debilitating primary immunodeficiency disorders, primarily caused by genetic mutations that disrupt T-cell development. SCID can also affect B-cell and natural killer cell function and counts. Left untreated, SCID proves fatal within the first year of life. The conventional treatment for SCID patients...
by Rachel Sauer, CU Anschutz Medical Campus Credit: CC0 Public Domain Cancer is a disease driven by gene mutations. These mutated genes in cancer fall into two major categories: tumor suppressors and oncogenes. Mutations in tumor suppressor genes can allow tumors to grow unchecked—a case of no brakes—while mutations in oncogenes can activate cell proliferation,...
by Albert Einstein College of Medicine The Listeria-tetanus toxoid (TT) delivery system infecting tumor cells and macrophages in pancreatic cancer tumors in mice. Credit: B. Chellakkan Selvanesan, et al., Science Translational Medicine (2022) Pancreatic cancer is notoriously difficult to cure or even treat. Now, a new strategy devised by scientists at Albert Einstein College of...
Maintaining vitamin D receptor levels in insulin-producing cells could protect against diabetes UNIVERSITAT AUTONOMA DE BARCELONA Maintaining vitamin D receptor (VDR) levels in pancreatic cells that synthesize and secrete insulin (β cells) could contribute to protecting against the development of diabetes and counteract pancreatic cell damage caused by the progression of the disease. This is...
