A Yale-led study provides new insights into the molecular and cellular development of supravalvular aortic stenosis (SVAS), a rare congenital heart defect caused by mutations or deletion of the elastin gene and characterized by narrowing of the aorta. The research, led by the Greif Lab in the Yale Cardiovascular Research Center, identified the role of the gene Notch3 in regulation...
Tag: <span>therapeutic target</span>
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Scientists find potential diagnostic and therapeutic target for lung cancer
JANUARY 17, 2022 by Chinese Academy of Sciences Proposed model for the LCDR/hnRNP K/LAPTM5 axis promoting the pathogenesis of lung cancer. Credit: Gao Shan Chinese scientists recently reported the key role in tumor survival played by a histone-acetylation-regulated long noncoding RNA called lysosome cell death regulator (LCDR), providing a potential diagnostic and therapeutic target for lung...
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Study presents novel therapeutic target for treatment of sepsis
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO IMAGE: THE STUDY ALSO PROVED THAT A DRUG ORIGINALLY INDICATED TO TREAT ALCOHOL DEPENDENCE CAN INHIBIT THE MOLECULE’S ACTION AND PREVENT COMPLICATIONS CREDIT: CRID-USP A new strategy for preventing complications associated with sepsis is presented by researchers affiliated with the University of São Paulo (USP)...
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Study reveals potential therapeutic target for genetic liver disease
by Melissa Rohman, Northwestern University Graphical abstract. Credit: DOI: 10.1016/j.molcel.2021.10.028 Northwestern Medicine investigators have discovered the molecular mechanisms underlying a rare genetic mutation that increases the risk of severe liver disease, according to findings published in Molecular Cell. The study, led by Deyu Fang, Ph.D., the Hosmer Allen Johnson Professor of Pathology, may reveal potential therapeutic...
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Enzyme driving insulin resistance in liver and may represent promising therapeutic target
by Marcela Quintanilla Dieck, Massachusetts General Hospital Graphical abstract. Credit: DOI: 10.1016/j.celrep.2021.109785 A central feature of type 2 diabetes is an inability of the body’s cells to respond to insulin, a hormone that keeps blood glucose levels normal. Critical to this balance is the liver, which both stores and manufactures glucose depending on the body’s need....
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Wistar scientists identify new therapeutic target in ovarian cancer subtype with poor prognosis
THE WISTAR INSTITUTE IMAGE: WISTAR’S DR. RUGANG ZHANG CREDIT: THE WISTAR INSTITUTE PHILADELPHIA — (Sept. 21, 2021) —Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress...
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A potential therapeutic target to treat cerebral blood alterations
by Autonomous University of Barcelona Image of a human cerebral artery (above) and a mouse cerebral artery (below) obtained using Raman microspectroscopy. The sphingosine-1-phosphate, located mainly in the arachnoid membrane, can be seen in pink. Credit: Autonomous University of Barcelona The arachnoid is one of the three meninges, or brain membranes, and is responsible for mechanically...
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New therapeutic target discovered for a number of aggressive cancers
A protein in tumour cells could be targeted to treat some types of aggressive cancer including brain, blood, skin, and kidney, new research has shown. The scientists, from the Wellcome Sanger Institute, University of Cambridge and Harvard University, have identified a protein that plays a key role in transforming normal tissue into cancer, as a possible target...
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Ovarian cancer: Potential therapeutic target identified
by Jeff Hansen, University of Alabama at Birmingham Intermediate magnification micrograph of a low malignant potential (LMP) mucinous ovarian tumour. H&E stain. The micrograph shows Simple mucinous epithelium (right) and mucinous epithelium that pseudo-stratifies (left – diagnostic of an LMP tumour). Epithelium in a frond-like architecture is seen at the top of the image. Credit: Nephron...
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New therapeutic target for Huntington’s treatment
by University of Barcelona A montage of three images of single striatal neurons transfected with a disease-associated version of huntingtin, the protein that causes Huntington’s disease. Nuclei of untransfected neurons are seen in the background (blue). The neuron in the center (yellow) contains an abnormal intracellular accumulation of huntingtin called an inclusion body (orange). Credit: Wikipedia/...