October 3, 2024 by Ari Navetta, Broad Institute of MIT and Harvard Epilepsy genetic architecture from large-scale genetic association studies. Credit: Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01747-8The largest and most diverse study to date of epilepsy’s genetic factors has revealed new potential targets for treatment, both shared by and unique to different subtypes of epilepsy. The...
Tag: <span>therapeutic targets</span>
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Single-cell map of heart failure suggests possible therapeutic targets
by Allessandra DiCorato, Broad Institute of MIT and Harvard Fibroblasts, a kind of connective tissue cell in the heart, showing cell nuclei (gray), tubulin (red), and actin (green). Credit: Maria (Masha) Kost-Alimova and Michelle Melanson, Center for the Development of Therapeutics Scientists from the Precision Cardiology Lab (PCL) of the Broad Institute of MIT and...
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Genetic study identifies migraine causes and promising therapeutic targets
by Queensland University of Technology Credit: Pixabay/CC0 Public Domain QUT genetic researchers have found blood proteins that cause migraine and have a shared link with Alzheimer’s disease that could potentially be prevented by repurposing existing therapeutics. Findings from the genetic analyses were published in Nature Communications by Professor Dale Nyholt and his Ph.D. candidate Hamzeh Tanha from the QUT...
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Atlas of migraine cell types sheds light on new therapeutic targets
by Brigham and Women’s Hospital Graphical abstract. Credit: Neuron (2022). DOI: 10.1016/j.neuron.2022.03.003. Headaches such as migraine are among the leading causes of morbidity worldwide, but most treatments provide only partial relief. While scientists know that migraine and related headaches are caused by activity in a part of the nervous system known as the trigeminal ganglion (TG), it...
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Just in the NIK of time
OSAKA UNIVERSITY IMAGE: NOVEL MECHANISM OF INTRAHEPATIC CHOLANGIOCARCINOMA DEVELOPMENT THROUGH TRANSDIFFERENTIATION OF HEPATOCYTES THROUGH DYSREGULATION OF TRAF3/NIK SIGNALING. CREDIT: YUTO SHIODE ET AL. Osaka, Japan – In a recent article published in Hepatology, a group led by researchers at Osaka University investigated the molecular mechanisms that drive development of Intrahepatic cholangiocarcinoma (ICC) – a cancer which...
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Study identifies SARS-CoV-2 spike conformation exposing potential new therapeutic targets
By Sally Robertson, B.Sc. Jul 14, 2021 Researchers in the United States have demonstrated that the viral spike protein used by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect host cells adopts an open conformation exposing novel epitopes that could serve as targets for therapeutic strategies to protect against coronavirus disease 2019 (COVID-19). The currently approved COVID-19...
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Study finds potential therapeutic targets to inhibit colorectal cancer progression
by Nagoya University Representative images of human colon cancer tissue showing the localization of gremlin 1-positive (left) and meflin-positive (right) cancer-associated fibroblasts (CAFs) in the stroma. Brown denotes CAFs that are positive for gremlin 1 or meflin T., tumor cells. Credit: Atsushi Enomoto Nagoya University researchers and colleagues have revealed that colorectal cancer tissues contain at least two...