by Children’s Medical Research Institute (CMRI) Credit: Cell Chemical Biology (2023). DOI: 10.1016/j.chembiol.2023.11.008 A team from Children’s Medical Research Institute has discovered a new way to impair cancer cell growth, which could lead to the development of a new class of cancer therapeutics with minimal side-effects on normal cells. Professor Hilda Pickett, who leads CMRI’s...
Posted Today Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body.DNA – artistic interpretation. DNA – artistic interpretation. Image credit: Alius Noreika, created with Bing Image Creator In a collaboration of universities, including Dr Lance Turtle at the University of Liverpool, researchers have...
NATIONAL UNIVERSITY OF SINGAPORE, YONG LOO LIN SCHOOL OF MEDICINE Multiple sclerosis (MS) is an autoimmune disease affecting the brain and spinal cord. In MS, the activated immune cells attack myelin, a protective layer surrounding nerve cells, which disrupts the transmission of nerve impulses along nerve cells. Over time, there is permanent damage or deterioration...
May 21, 2021 By Cade Hildreth (CEO) Exosomes are extracellular vesicles (EVs) of endosomal origin that range in size between 30 and 150 nanometers. Exosomes are secreted by a wide range of cells, since virtually all living cells utilize exosome-mediated communication. Exosomes carry cell-specific cargos of proteins, lipids, and nucleic acids that are selectively taken...
Nicole DeFeudis Associate Editor Visus Therapeutics is off to a bit of a late start in the race for a therapeutic alternative to reading glasses. But with an added $36 million in the bank, CEO Ben Bergo is eyeing a quick Phase II launch for the company’s double-agent eye drops. Bergo co-founded Visus back in...
by Marissa Shapiro, Vanderbilt University Credit: CC0 Public Domain Vanderbilt researchers have discovered a unique pathway that initiates islet β cell inflammation—a hallmark of type 2 diabetes—putting them a step closer to developing targeted therapeutics for the disease that affects one in 10 Americans. The article, “RIPK3-mediated inflammation is a conserved β-cell response to ER stress” was published...
UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER IMAGE: BASED ON VIRTUAL AND IN VITRO ANTIVIRAL SCREENING THAT BEGAN IN THE EARLIER MONTHS OF THE COVID-19 PANDEMIC, THE RESEARCHERS LED AT UTHSC BY COLLEEN JONSSON, PHD, IDENTIFIED ZUCLOPENTHIXOL, NEBIVOLOL AND AMODIAQUINE AS A PROMISING THERAPEUTICS FOR TEH VIRUS IN ITS EARLY STAGES. Memphis, Tenn. (November 18, 2020)–Researchers at...
On January 10, Chinese researchers posted the novel coronavirus’ RNA sequence on a preprint server. Immediately, scientists who study genetic vaccines turned their efforts to the emerging pathogen that causes coronavirus disease 2019 (COVID-19). They knew that rapid response genetic platforms could shave precious weeks to months off development, crucial during a pandemic. They were...
ASSOCIATE PROFESSOR OF PATHOLOGY, MEMBER OF THE PITTSBURGH LIVER RESEARCH CENTER AND THE MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE view more CREDIT: UNIVERSITY OF PITTSBURGH PITTSBURGH, Sept. 3, 2020 – Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the case of CRISPR-based gene therapies, molecular scissors...
New findings may provide new therapeutic target and help explain why IBD and other autoimmune diseases are often chronic and life-long UNIVERSITY OF CALIFORNIA – SAN DIEGO COLORIZED SCANNING ELECTRON MICROGRAPH OF A T CELL, A TYPE OF LYMPHOCYTE THAT PLAYS A CENTRAL ROLE IN THE IMMUNE RESPONSE. view more CREDIT: NIAID Inflammatory bowel disease...
