by Northumbria University Research from Northumbria University, Newcastle, has shown the important role specific types of exercise can play in the management of bone loss, fatigue and muscle dysfunction for those with Crohn’s disease. Crohn’s disease is a type of inflammatory bowel disease which is estimated to affect about one in every 650 people in...
Tag: <span>Therapeutics</span>
Scientists decipher key mechanism in hypoxia
by Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) The figure illustrates the role of the mitochondrial Ca2+/Na+ exchanger (NCLX) in the early adaptation to low oxygen concentrations (hypoxia) through the entry of sodium into the mitochondrial interior. This role is exemplified by hypoxic vasoconstriction of the pulmonary artery, which connects the heart to the...
Novel diabetes drug candidate shows promising properties in human islets and mouse models
The drug candidate is a non-toxic small molecule that given orally effectively rescued mice from models of Type 1 and Type 2 diabetes UNIVERSITY OF ALABAMA AT BIRMINGHAM ANATH SHALEV FROM UNIVERSITY OF ALABAMA AT BIRMINGHAM view more CREDIT: UAB BIRMINGHAM, Ala. – The University of Alabama at Birmingham and Southern Research have discovered a...
Phage therapy shows potential for treating prosthetic joint infections
ROCHESTER, Minn. — Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic research. The findings suggest phage therapy could provide a potential treatment for managing such infections, including those involving antibiotic-resistant microbes. The research is published in the July issue of Clinical Infectious...
AsEH enzyme: A new pharmacological target against Alzheimer’s disease
Drugs with neuroprotector effects UNIVERSITY OF BARCELONA FROM LEFT TO RIGHT, SANTIAGO VÁZQUEZ, CARLES GALDEANO, MERCÈ PALLÀS AND CHRISTIAN GRIÑÁN-FERRÉ (FACULTY OF PHARMACY AND FOOD SCIENCES/UNIVERSITY OF BARCELONA)…. view more CREDIT: UNIVERSITY OF BARCELONA A UB study published in the journal Neurotherapeutics has validated a new pharmacological target for Alzheimer’s disease. The results show the...
Researchers identify a cancer metabolic pathway that could be a valuable target for therapy
by Sonia Fernandez, University of California – Santa Barbara Fighting cancer often means employing a suite of techniques to target the tumor and prevent it from growing and spreading to other parts of the body. It’s no small feat—the American Cancer Society predicts roughly 1.8 million new cases of cancer in the country in 2020,...
Moffitt researchers find dual inhibitor may be safer for CLL patients
Treatment with the PI3K/ CK1ε inhibitor umbralisib showed fewer immune-mediated adverse reactions compared to PI3K inhibitor therapy H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE TAMPA, Fla. — Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. One in four new leukemia cases are CLL. Early-stage CLL patients often do not require therapy,...
Bridge, The Opioid Withdrawal Therapy Device, Released by Masimo
Masimo has announced that it’s making the Bridge device available, the first electronic therapeutic solution for tackling opioid withdrawals. Originally developed by Innovative Health Solutions, a Versailles, Indiana firm, the Bridge delivers neuromodulation to a set of occipital and cranial nerves (V, VII, IX, and X) via electrodes attached near the ear. The therapy helps...
Discovery of a novel drug candidate to develop effective treatments for brain disorders
The study published in Chem is fundamental to develop pharmacological drugs for the treatment of core symptoms in Down syndrome, autism and other brain disorders. Researchers aim to create a start-up company with the support of interested investors ISTITUTO ITALIANO DI TECNOLOGIA – IIT THE PROTEIN NKCC1 IS A TRANSPORTER OF IONS IN THE BRAIN;...
Researchers find promising therapy to fight epidemic of liver disease
So far there are no approved drugs for Non-Alcoholic Fatty Liver Disease UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS AURORA, Colo. (July 8, 2020) – In an effort to combat a growing worldwide epidemic of Nonalcoholic Fatty Liver Disease (NAFLD), scientists have discovered a new target and a new therapy that has shown promising results in...