Promoting blood brain barrier health by reducing elevated pulse pressure in blood could be a promising new preventative solution and/or treatment for dementia. A recent paper published in Frontiers in Neuroscience, outlines a pulse-pressure-induced pathway of cognitive decline that sheds light on why previous treatments for dementia may have failed and proposes promising new directions...
Tag: <span>Therapeutics</span>
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Blocking a ‘jamming signal’ can unleash immune system to fight tumors
by Yale University Yale researchers have discovered a “jamming signal” that blocks a powerful immune system stimulant called interleukin-18 (IL-18) from reaching tumors, including in cancers that are resistant to conventional immunotherapy treatments, they report June 24 in the journal Nature. The research team created a version of IL-18 that could not be jammed and...
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Research uncovers clues in use of immunotherapy for breast cancer
by University of Cincinnati UC researchers have found a potential new combination therapy for breast cancer that would integrate use of the body’s immune system with targeted treatment for a particular protein that advances cancer. The study, published in the journal Cancer Research, a journal of the American Association for Cancer Research, provides data that...
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The regulation of glycemia after stroke improves neurological recovery in diabetes
In a study in mice, researchers at Karolinska Institutet have discovered a new potential therapeutic approach to facilitate neurological recovery in people with diabetes suffering from a stroke. The treatment strategy is based on the chronic normalization of hyperglycemia after stroke. The scientists hope that these new results, presented in the scientific journal Diabetes, open...
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What are Furin Proteases?
By Benedette Cuffari, M.Sc. Reviewed by Emily Henderson, B.Sc. In order to develop appropriate treatments and vaccines to combat the novel coronavirus, otherwise known as SARS-CoV-2 or COVID-19, researchers around the world have carefully examined every microscopic component of this potent virus. What is protease? The term protease is used to describe a large group...
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Researchers say genetics may determine wound infection and healing
A recent study led by Texas Tech’s Department of Biological Sciences and Natural Science Research Laboratory determined that certain genes are associated with the pathogens that infect chronic wounds and hinder the healing process. CALEB PHILLIPS; ASSISTANT PROFESSOR OF BIOLOGICAL SCIENCES AND DIRECTOR OF THE PHILLIPS LABORATORY, COLLEGE OF ARTS & SCIENCES; CURATOR OF GENETIC...
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Squid studies illuminate neural dysfunction in ALS; suggest new route to therapy
CREDIT: DANIEL COJANU WOODS HOLE, Mass. — Amyotrophic lateral sclerosis (ALS) is one of the most devastating adult-onset neurodegenerative diseases. Patients, including the late actor/playwright Sam Shepard, become progressively weaker and eventually paralyzed as their motor neurons degenerate and die. To find a cure for ALS, which is fatal, scientists need a deeper understanding of...
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Diluting blood plasma rejuvenates tissue, reverses aging in mice
New study suggests that plasma exchange could be the key to unlocking the body’s regenerative capacities UNIVERSITY OF CALIFORNIA – BERKELEY CREDIT: IMAGE COURTESY IRINA CONBOY Berkeley — In 2005, University of California, Berkeley, researchers made the surprising discovery that making conjoined twins out of young and old mice — such that they share blood...
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Researchers find a new therapeutic target in pancreatic cancer
by Dartmouth-Hitchcock Medical Center The development of pancreatic cancer is driven by co-existing mutations in an oncogene involved in controlling cell growth, called KRAS, and in a tumor suppressor gene, called p53. But how these mutations cooperate to promote cancer is unknown. A new study co-led by Steven Leach, MD, Director of Dartmouth’s and Dartmouth-Hitchcock’s...
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New test paves the way for tailored treatment of deadliest form of ovarian cancer
by University of British Columbia University of British Columbia (UBC) researchers have led an international team in developing a new test to better diagnose different types of ovarian cancer, a tool that could one day guide and improve treatment options for women diagnosed with the most common and deadliest form of the disease. The development...