by University of Barcelona An interdisciplinary research study of the University of Barcelona identified two potential candidates to treat Alzheimer’s disease. These are two marine molecules, meridianine and lignarenone B, able to alter the activity of GSK3B activity, a protein associated with several neurodegenerative diseases. The researchers used several biocomputational techniques to detect these so...
Tag: <span>Therapeutics</span>
Genetic database provides rare disease clues and Parkinson’s hope
by Kate Wighton, Imperial College London Scientists have created the world’s largest publicly available database of genetic variants—changes in DNA that can sometimes lead to disease. The use of this resource, called the Genome Aggregation Database (gnomAD) and including information from over 140,000 people from across the globe, is described in a landmark collection of...
The new COVID-19 drug remdesivir is here. Now what?
Short supplies and limits on who qualifies mean more options are needed to end the pandemic Remdesivir production Gilead Sciences plans to ramp up production of remdesivir, one of the first antiviral drugs to help COVID-19 patients recover, in order to provide 1 million 10-day course of treatment by year’s end. GILEAD SCIENCES Share this:...
Unusual immune response in bladder appears to drive repeat UTIs
by Sarah Avery, Duke University As many people know, bladder infections can be a painful and recurring condition, and those who are prone to the infections often report they have to “go” with greater frequency and urgency. These two related conditions are caused by an aberrant immune response that prioritizes repairing tissue in the bladder...
Scientists identify gene linked to thinness that may help resist weight gain
by Cell Press While others may be dieting and hitting the gym hard to stay in shape, some people stay slim effortlessly no matter what they eat. In a study publishing May 21 in the journal Cell, researchers use a genetic database of more than 47,000 people in Estonia to identify a gene linked to...
Legal Cannabis hemp oil effectively treats chronic neuropathic pain: study
by University of New Mexico Researchers examine the effectiveness of consuming hemp oil extracted from the whole Cannabis plant using a chronic neuropathic pain animal model. Researchers at The University of New Mexico (UNM) showed that legal Cannabis hemp oil reduced mechanical pain sensitivity 10-fold for several hours in mice with chronic post-operative neuropathic pain....
Bone health declining in U.S. adults with and without prediabetes
(HealthDay)—The bone health of adults older than 40 years of age is declining for individuals both with normal glucose regulation and prediabetes, according to a study recently published in Diabetes Care. Chi Chen, M.D., from the Shanghai Jiao Tong University School of Medicine, and colleagues used data from the U.S. National Health and Nutrition Examination...
Treatment with interferon-α2b speeds up recovery of COVID-19 patients in exploratory study
by Frontiers Treatment with antivirals such as interferons may significantly improve virus clearance and reduce levels of inflammatory proteins in COVID-19 patients, according to a new study in Frontiers in Immunology. Researchers conducting an exploratory study on a cohort of confirmed COVID-19 cases in Wuhan found that treatment with interferon (IFN)-α2b significantly reduced the du-ration...
Single-cell RNA seq developed to accurately quantify cell-specific drug effects in pancreatic islets
by CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences The pancreas is an abdominal organ that produces digestive enzymes as well as hormones that regulate blood sugar levels. This hormone-producing function is localized to the islets of Langerhans, which constitute clusters of different endocrine cell types. Among those are beta cells,...
Researcher designs robot-assisted care system for speech and language therapy
by Asociacion RUVID Improving the treatment of dyslalia, a disorder that causes the incorrect pronunciation of phonemes, is the purpose of the robot-assisted care system designed by Eldon Glen Caldwell, Ph.D. in Computer Engineering from the University of Alicante. It consists of a platform combining a robot with a mobile device application that increases therapeutic...