Marlene Busko March 03, 2023 Hydrochlorothiazide, which for decades has been a standard treatment to prevent the recurrence of calcium-containing kidney stones, did not lower the rate of stone recurrence in the NOSTONE randomized controlled trial. The rate of stone recurrence within 3 years was similar among 416 patients randomly assigned to receive hydrochlorothiazide 12.5 mg, 25 mg, or 50...