Tag: <span>TIAM1 Antagonizes</span>

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TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells

Highlights TIAM1 is part of the WNT-regulated destruction complex regulating TAZ/YAP stability WNT induces TIAM1 nuclear translocation where it reduces TAZ/YAP-TEAD interaction Nuclear TIAM1 blocks the TAZ/YAP genetic program inhibiting migration of CRC cells Nuclear TIAM1 predicts good prognosis in CRC Summary Aberrant WNT signaling drives colorectal cancer (CRC). Here, we identify TIAM1 as a...