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Normal-appearing tissue offers insights into lesion formation in multiple sclerosis

by Netherlands Institute for Neuroscience Microglia nodules in MS are more frequent than in stroke but are similar in size. IHC stainings with HLA and PLP shown in brown. Quantifications performed on n = 8 MS and n = 8 stroke donors. a PLP and HLA staining of (NA)WM matter in MS and in stroke shows no sign of demyelination...