Tag: <span>toxcity</span>

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MEK Inhibitor Mechanism of Action, Side Effects, and Uses

By Dr. Liji Thomas, MDReviewed by Dr. Jennifer Logan, MD, MPH Metastatic melanoma is a deadly cancer for which conventional chemotherapy provides little benefit. However, newer therapies involving a pathway called the mitogen-activated protein kinase (MAPK) pathway have demonstrated success in inducing remission. The MAPK pathway is more accurately termed the RAS-RAF-MEK-ERK pathway, and involves...