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Cleaning up toxic ‘protein clumps’ could prevent dementia
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Cleaning up toxic ‘protein clumps’ could prevent dementia

by University of Queensland Credit: Queensland Brain Institute The clean-up of cellular “protein clumps” could prevent the onset of some types of dementia, according to a new study from The University of Queensland. Researchers from the Queensland Brain Institute made the discovery after focusing on the relationship between the enzyme Fyn and the protein Tau...

New insights into the formation of toxic protein clumps in Alzheimer’s disease
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New insights into the formation of toxic protein clumps in Alzheimer’s disease

by  Forschungszentrum Juelich Small Aβ oligomers (left: cryo-electron microscopy) are clumps consisting of just a few Aβ molecules. They cluster together to form short, worm-like structures known as protofibrils (right: atomic force microscopy). In an acidic environment, the Aβ oligomers form very quickly and cluster to form large particles from which protofibrils are separated following neutralization...