VANDERBILT UNIVERSITY MEDICAL CENTER After a cancer patient receiving an immunotherapy developed encephalitis and died 18 months into treatment, researchers at Vanderbilt-Ingram Cancer Center (VICC) investigated why the complication occurred, performing a molecular analysis of the disease’s pathology and mining data to determine the incidence of similar occurrences. The molecular analysis revealed the presence of...
Tag: <span>toxicity</span>
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New approach to Cancer Immunotherapy overcomes toxicity hurdle
In an effort to develop more effective cancer treatments, scientists are looking for therapies that supercharge patients’ immune systems. One possibility is to use antibodies that activate CD40, an immune-cell protein that, when triggered, prompts the rest of the immune system to spring into action. Credit: CC0 Public Domain Though promising, drugs that target CD40...
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Physical exercise improves the elimination of toxic proteins from muscles
A study published in Scientific Reports by researchers at the University of São Paulo (USP) in Brazil, in partnership with colleagues in the United States and Norway, shows that the lack of muscle stimulus results in a buildup of inadequately processed proteins in muscle cells and consequently leads to muscle weakness or wasting. Credit: Peter...
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Compounds found in green tea and wine may block formation of toxic metabolites
Discovery may pave the way for therapies to treat inborn congenital metabolic disorders, Tel Aviv University researchers say AMERICAN FRIENDS OF TEL AVIV UNIVERSITY A new Tel Aviv University study suggests there is hope of treating certain inborn congenital metabolic diseases — a hope found in green tea and in red wine. Most people with inherited metabolic...
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Hypervitaminosis A: What to know
Hypervitaminosis A is a condition that occurs when a person has too much vitamin A in their body. This can happen if a person takes too many supplements or uses certain creams for acne over a prolonged period. Symptoms of hypervitaminosis A include vision problems, changes in the skin, and bone pain. Chronic cases of...