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Genetically Modified Pluripotent Stem Cells May Evade Immunological Rejection After Transplantation
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Genetically Modified Pluripotent Stem Cells May Evade Immunological Rejection After Transplantation

Researchers say the genetically engineered stem cells also could pave the way for new regenerative medicine treatments for diseases such as Type 1 diabetes. Deepta Bhattacharya, who is on the University of Arizona Health Sciences Center for Advanced Molecular and Immunological Therapies advisory council, is a professor of immunobiology in the UArizona College of Medicine...

Risk for vitiligo increased for transplant recipients
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Risk for vitiligo increased for transplant recipients

by Elana Gotkine Transplant recipients, especially those receiving hematopoietic stem cell transplant (HSCT), have an increased risk for vitiligo, according to a brief report published online Dec. 13 in JAMA Dermatology. Chul Hwan Bang, M.D., Ph.D., from the Catholic University of Korea in Seoul, and colleagues conducted a population-based cohort study including data from the...

Fecal microbiota transplants: Two reviews explore what’s worked, what hasn’t, and where we go from here
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Fecal microbiota transplants: Two reviews explore what’s worked, what hasn’t, and where we go from here

by Cell Press Credit: CC0 Public Domain Fecal microbiota transplants are the most effective and affordable treatment for recurrent infections with Clostridioides difficile, an opportunistic bacterium and the most common cause of hospital-acquired intestinal infections. However, attempts to treat chronic noncommunicable diseases such as ulcerative colitis and metabolic syndrome via fecal microbiota transplantation (FMT) have yielded...

New islet transplant method leads to insulin independence
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New islet transplant method leads to insulin independence

by Perelman School of Medicine at the University of Pennsylvania A pancreatic islet from a mouse in a typical position, close to a blood vessel; insulin in red, nuclei in blue. Credit: Generated in the Solimena lab, Paul Langerhans Institute Dresden More than half of the most seriously affected type 1 diabetes patients achieved years...

New blood: Lab-grown stem cells bode well for transplants, aging research
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New blood: Lab-grown stem cells bode well for transplants, aging research

UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: THE HSF1-MEDIATED HEAT SHOCK PATHWAY PROMOTES PROTEOSTASIS IN HEMATOPOIETIC STEM CELLS IN CULTURE AND DURING AGING. CREDIT: CELL STEM CELL Hematopoietic stem cells — the precursors to blood cells — have been notoriously difficult to grow in a dish, a critical tool in basic research. Scientists at University of...

A ‘cell-less’ therapy may regenerate heart tissue without cell transplant risks
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A ‘cell-less’ therapy may regenerate heart tissue without cell transplant risks

AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE IMAGE: AN EXOSOME DERIVED FROM HEART CELLS GROWN FROM HUMAN INDUCED PLURIPOTENT STEM CELLS. THIS MATERIAL RELATES TO A PAPER THAT APPEARED IN THE SEP. 16, 2020, ISSUE OF SCIENCE TRANSLATIONAL. Ling Gao and colleagues have developed a strategy that uses exosomes – tiny membrane-bound sacs secreted by cells –...