In a recent study, Japanese scientists have developed a novel concept of a nose-to-brain system for the clinical application of neuropeptides. They developed a derivative of glucagon-like peptide-2 and found that when administered intranasally, it is efficiently delivered through the trigeminal nerve to the site of action and exhibits antidepressant-like effects. This is the first...
Tag: <span>trigeminal nerves</span>
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The nose-brain pathway: exploring the role of trigeminal nerves in delivering intranasally administered antidepressant
TOKYO UNIVERSITY OF SCIENCE IMAGE: INTRANASAL ADMINISTRATION OF PAS-CPP-GLP-2 RESULTS IN ITS DELIVERY TO THE BRAIN VIA TRIGEMINAL AXONS OF THE TRIGEMINAL NERVES. THEREFORE, IT IS THOUGHT TO CONSTITUTE A NERVE-ASSOCIATED TRANSCELLULAR PATHWAY FOR DRUG DELIVERY. CREDIT: PROF. CHIKAMASA YAMASHITA FROM TOKYO UNIVERSITY OF SCIENCE Intranasal (in.) administration has been garnering increasing popularity as a...