TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE IMAGE: IN NORMAL NEURONS, ONLY CERTAIN PARTS ARE SPONTANEOUSLY ACTIVATED. LOSS OF FUNCTION OF MUTATIONS IN TSC1 OR TSC2 LEADS TO HYPERACTIVATION OF MTOR. HYPERACTIVATED MTOR INCREASES LTCC EXPRESSION AND CAUSES A LARGE CA2+ INFLUX UPON NEURONAL ACTIVATION IN TSC NEURONS. INCREASED CA2+ INFLUX CAUSES ABNORMAL AXONAL EXTENSIONS AND...
