MAY 20, 2024 by Melissa Rohman, Northwestern University High-grade meningiomas are distinguished by regionally distinct intratumor immune infiltration, MAPK signaling, PI3K-AKT signaling, and cell proliferation. Credit: Amy B. Heimberger, MD, Ph.D. Investigators have discovered new mechanisms underlying the diversity of characteristics within a single tumor, as well as treatment resistance, in the most common type...
by Lauran Neergaard This combination of MRI scan images provided by the New England Journal of Medicine in March 2024 shows the progress of a glioblastoma patient who received CAR-T therapy which uses modified versions of T cells from a patient’s own immune system. Studies published by the New England Journal of Medicine on Wednesday,...
Patients diagnosed with esophageal cancer have low chances of survivalBut a test could detect signs of the cancer before it develops allowing treatment A vitamin pill-sized device could revolutionize the battle against a deadly throat cancer by diagnosing patients before they develop the disease. Patients diagnosed with esophageal cancer have just a 50 percent chance...
by University of Vienna Immunofluorescence image of the expression of PHGDH (red) and CD3 T cells (green) in cryosectioned AE17 mesothelioma. Credit: Zhengnan CaiA study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in Cellular & Molecular Immunology, shows that the enzyme phosphoglycerate dehydrogenase (PHGDH) acts as a metabolic...
by University of Birmingham Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.113568 A highly aggressive common form of leukemia which is activated by mutations in signaling molecules is maintained by a web of regulatory proteins downstream of these signals. New research published in Cell Reports shows that a complex network of interacting genes activated by this altered signaling...
Donavyn Coffey February 17, 2023 UPDATED February 23, 2023 // Editor’s note: The headline of this article was changed from “New Cancer Screen, Same Issues: Physicians Confront Galleri Test” to better reflect the content of the article. In January 2022, Anthony Arenz, a 51-year-old living in Mesa, Arizona, breathed a small sigh of relief. The Galleri blood test,...
by University of Texas M. D. Anderson Cancer Center Katy Rezvani, M.D., Ph.D., working in her laboratory. Credit: MD Anderson Cancer Center Researchers at The University of Texas MD Anderson Cancer Center have developed a new approach to engineering natural killer (NK) cells with a second chimeric antigen receptor (CAR) to act as a logic gate,...
by Will Doss, Northwestern University Pharmacological inhibitor of MLCK MW01-022AZ suppressed tumor inflammation and growth. a Schematic of LLC lung tumor implantation in C57Bl6 mice and MW01-022AZ treatment. b–d Effect of MW01-022AZ on LLC b gross tumor morphology (n = tumors from 6 mice) c tumor volume (n = 9 mice and d tumor weight at endpoint (21 days)...
The fluorine-based agent replaces an iodine-based agent developed decades ago at the University of Michigan. A new study shows that researchers have developed a noninvasive method to identify a potential cause of hypertension with a drastic reduction in radiation exposure. Around 10-15% cases of hypertension, or high blood pressure, are believed to be caused by excessive production...
by University of Strathclyde, Glasgow Microfluidic tumor-stromal co-culture for CAR-T studies. (A) Image of the OC3D Single microfluidic device used (ScreenIn3D Ltd, U.K.) with schematic showing principle of cell seeding. A single-cell suspension flows through a microchannel and cells sediment into microwell traps below the microchannel level. Scale bar = 10 mm. (B) Brightfield and fluorescence images...
