New method of transporting drugs published in Nature Nanotechnology JOHANNES GUTENBERG UNIVERSITAET MAINZ Scientists at the Mainz University Medical Center and the Max Planck Institute for Polymer Research (MPI-P) have developed a new method to enable miniature drug-filled nanocarriers to dock on to immune cells, which in turn attack tumors. In the future, this may...
Tag: <span>Tumor</span>
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A new therapy proves effective against brain metastasis
A study published in Nature Medicine by a team led by Manuel Valiente, head of the Brain Metastasis Group at the Spanish National Cancer ResearchCentre (CNIO), shows that the administration of silibinin in patients with brain metastasis reduces lesions without causing any adverse effects. This preliminary trial provides proof of concept that this compound could be a new...
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Cell surface protein plays an integral role in tumor growth and sustenance
Researchers at Okayama University describe in the journal Scientific Reports the role of an extracellular protein, versican, in regulating tumor growth and providing a newly formed network of blood vessels to further nourish the tumor. Angiogenesis is the creation of new blood vessels from the branching of pre-existing ones. This phenomenon is especially important in the context...
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Gallbladder cancer: Pharmacist finds protein that drives tumor growth
Patients with gallbladder cancer often show few or no symptoms for long periods of time. As a result, the tumours are only detected at a late stage of the disease when treatment is often no longer possible. Working in collaboration with pathologists at the University of Magdeburg, Sonja M. Kessler, a research pharmacist in the...
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Rare benign tumors hold the ‘genetic recipe’ to combat diabetes
Rare benign tumors known as insulinomas contain a complicated wiring diagram for regeneration of insulin-producing human beta cells, which may hold the key to diabetes drug development, researchers at the Icahn School of Medicine at Mount Sinai report. The study, titled “Insights into Beta Cell Regeneration for Diabetes via Integration of Molecular Landscapes in...
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UMass Amherst Researchers Find ‘Switch’ That Turns on Immune Cells’ Tumor-killing Ability
AMHERST, Mass. – Molecular biologists led by Leonid Pobezinsky and his wife and research collaborator Elena Pobezinskaya at the University of Massachusetts Amherst have published results that for the first time show how a microRNA molecule known as Lethal-7 (let-7) serves as a molecular control hub to direct the function of cytotoxic T lymphocytes by...
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Molecular hitchhiker on human protein signals tumors to self-destruct
Powerful molecules can hitch rides on a plentiful human protein and signal tumors to self-destruct, a team of Vanderbilt University engineers found. Their research gives oncologists a better shot at overcoming the problems of drug resistance, toxicity to patients and a host of other barriers to consistently achieving successful gene therapy for cancer. It is...
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New device detects tumor cells in blood
A team of researchers has patented a mobile device that can monitor cancer quickly, cheaply, effectively and noninvasively IMAGE: THE DEVICE IN OPERATION: A FIBER OPTIC SHINES A BLUE LIGHT ON THE SAMPLE, HIGHLIGHTING THE CELLS AS THEY FLOW FROM LEFT TO RIGHT. Researchers at the URV’s Department of Physical and Inorganic Chemistry, led by...
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Specialized blood vessels enhance tumor-fighting Immunotherapy
Researchers from VIB and KU Leuven, together with colleagues from the University of California and the Swiss Institute for Experimental Cancer Research have demonstrated that, anti-angiogenic therapy can improve immune boosting treatments. The combination of these two therapies result in the growth of specialized vessels that deliver cancer-fighting immune cells to the tumor, potentially leading...
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Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies
T cell dysfunction in solid tumors results from multiple mechanisms. Altered signaling pathways in tumor cells help produce a suppressive tumor microenvironment enriched for inhibitory cells, posing a major obstacle for cancer immunity. Metabolic constraints to cell function and survival shape tumor progression and immune cell function. In the face of persistent antigen, chronic T cell receptor...