Rare benign tumors known as insulinomas contain a complicated wiring diagram for regeneration of insulin-producing human beta cells, which may hold the key to diabetes drug development, researchers at the Icahn School of Medicine at Mount Sinai report. The study, titled “Insights into Beta Cell Regeneration for Diabetes via Integration of Molecular Landscapes in...
Tag: <span>Tumor</span>
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UMass Amherst Researchers Find ‘Switch’ That Turns on Immune Cells’ Tumor-killing Ability
AMHERST, Mass. – Molecular biologists led by Leonid Pobezinsky and his wife and research collaborator Elena Pobezinskaya at the University of Massachusetts Amherst have published results that for the first time show how a microRNA molecule known as Lethal-7 (let-7) serves as a molecular control hub to direct the function of cytotoxic T lymphocytes by...
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Molecular hitchhiker on human protein signals tumors to self-destruct
Powerful molecules can hitch rides on a plentiful human protein and signal tumors to self-destruct, a team of Vanderbilt University engineers found. Their research gives oncologists a better shot at overcoming the problems of drug resistance, toxicity to patients and a host of other barriers to consistently achieving successful gene therapy for cancer. It is...
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New device detects tumor cells in blood
A team of researchers has patented a mobile device that can monitor cancer quickly, cheaply, effectively and noninvasively IMAGE: THE DEVICE IN OPERATION: A FIBER OPTIC SHINES A BLUE LIGHT ON THE SAMPLE, HIGHLIGHTING THE CELLS AS THEY FLOW FROM LEFT TO RIGHT. Researchers at the URV’s Department of Physical and Inorganic Chemistry, led by...
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Specialized blood vessels enhance tumor-fighting Immunotherapy
Researchers from VIB and KU Leuven, together with colleagues from the University of California and the Swiss Institute for Experimental Cancer Research have demonstrated that, anti-angiogenic therapy can improve immune boosting treatments. The combination of these two therapies result in the growth of specialized vessels that deliver cancer-fighting immune cells to the tumor, potentially leading...
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Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies
T cell dysfunction in solid tumors results from multiple mechanisms. Altered signaling pathways in tumor cells help produce a suppressive tumor microenvironment enriched for inhibitory cells, posing a major obstacle for cancer immunity. Metabolic constraints to cell function and survival shape tumor progression and immune cell function. In the face of persistent antigen, chronic T cell receptor...