By ADAM FEUERSTEIN @adamfeuerstein Scientists have long known that a mutant form of the cell-signaling protein called KRAS causes cancer, but discovering drugs capable of blocking KRAS has proven difficult. The protein is spherical and nearly featureless — its structure has been compared to a tennisball — leaving potential drugs with few, if any, effective attachment points....
Tag: <span>Tumor</span>
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NeurExo Sciences and Henry Ford present preclinical data on exosomes at ISEV2019
Exosomes demonstrate ability to enhance anti-tumor effect of platinum-based drugs and to ameliorate peripheral neuropathy HENRY FORD HEALTH SYSTEM NeurExo Sciences, LLC (NXS), a biotechnology company focused on the development of exosome therapies and subsidiary of NeuroTrauma Sciences LLC, and Henry Ford Health System, a non-profit organization, today announced the presentation of new data on exosomes at the International Society for Extracellular Vesicles (ISEV) 2019 Annual Meeting being...
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This neurotransmitter helps aggressive tumors spread
By Maria Cohut Fact checked by Jasmin Collier New research has looked at human cancer cells implanted into mice, human tumor samples, and other assays in an attempt to better understand what drives the spread of certain aggressive cancers. A team at Johns Hopkins Medicine in Baltimore, MD, has recently conducted a study, the results of which...
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Targeted therapy proves effective against aggressive rare blood cancer
by Dana-Farber Cancer Institute A multi-institutional clinical trial has given good results for a targeted therapy to treat a rare, aggressive blood cancer known as blastic plasmacytoid dendritic-cell neoplasm (BPDCN). Details on the trial, which supported Food and Drug Administration approval of the tagraxofusp therapy in December 2018, have been published in the New England Journal of Medicine....
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Researchers pinpoint tumor-related protein, slow progression of cancers
by University of Nebraska-Lincoln Locking a biochemical gate that admits fuel into immune-suppressing cells could slow tumor progression and assist the treatment of multiple cancers, says new research from the Wistar Institute, the University of Nebraska-Lincoln and others. Published April 17 in the journal Nature, the study found elevated levels of fatty acid transporter protein 2, or FATP2, in a type of...
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New ‘Trojan horse’ cancer treatment shows early promise in multiple tumor types
A brand new type of cancer drug that acts as a ‘Trojan horse’ to get inside tumour cells has shown promise in patients with six different cancer types. In patients with advanced, drug-resistant cancers, over a quarter with cervical and bladder tumours, and nearly 15 per cent with ovarian and lung tumours, responded to the...
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Cardiff University researchers shed light on development of gastric cancer
Cardiff University researchers have uncovered new information about the underlying mechanisms for gastric cancer, providing hope of potential new therapies in the future. The team, at the University’s European Cancer Stem Cell Research Institute, found they could stop gastric cells dividing and growing by deleting a particular cell-surface receptor implicated in the function of stem...
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Opposite effect: Protein widely known to fight tumors also boosts cancer growth
Search for a description of “p53” and it becomes clear that this human protein is widely known for its cancer-fighting benefits, leading to its renown as “the guardian of the genome.” IMAGE: UC SAN DIEGO RESEARCHERS FOUND THAT THE PUMA PROTEIN WORKS INSIDE THE CELL’S MITOCHONDRIA TO SWITCH ENERGY PRODUCTION PROCESSES AND STIMULATE CANCER GROWTH.view...
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Study identifies two proteins that suppress tumor growth in fruit flies, suggests similar effect on human cancers
The concept sounds simple, but understanding the process has been elusive: Cut off the nutrient supply to suppress the growth of tumors. The protein “Headcase,” or Hdc, functions together with the protein “Unkempt,” or Unk, to regulate tissue growth in fruit flies. Credit: Kansas State University Now researchers in the College of Veterinary Medicine at...
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Progress in the fight against brain cancer
A series of steps shows hope for improving treatments. “I knew it was serious from the sober demeanor of the medical professionals in the room.” That was how US Senator John McCain described his diagnosis of cancer in his 2018 book The Restless Wave. “And when someone, I don’t remember who, mentioned that it was...