by UT Southwestern Medical Center 6TdG induces double stranded breaks and apoptosis in mouse tumors. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-44861-8A molecule has demonstrated its ability to kill tumor cells and incite an immune response in preclinical models of small cell lung cancer (SCLC), according to UT Southwestern Medical Center researchers. The findings, published in...
CONN HASTINGS MEDICINE, NANOMEDICINE, ONCOLOGY Scientists at ETH Zurich in Switzerland have unveiled a technique that weaponizes bacterial cells against tumors. The approach involves using bacteria called Magnetospirillum that are naturally magnetic by virtue of the iron oxide particles they contain. The researchers use a rotating magnetic field applied at the tumor location from outside...
CONN HASTINGS MEDICINE, NANOMEDICINE, ONCOLOGY Researchers at The University of Texas MD Anderson Cancer Center have developed a nanotechnology platform that can make cancer cells more vulnerable to immune attack in the body. The researchers call their system the bispecific tumor-transforming nanoconjugate (BiTN) platform. The idea is to make solid tumors more appealing for the...
US researchers spotted a ‘switch’ that causes cancer cells to self-destructThe team now hopes to develop a treatment that targets this part of the cellBy EMILY CRAIG DEPUTY HEALTH EDITOR FOR MAILONLINE PUBLISHED: 05:45 EDT, 25 October 2023 | UPDATED: 05:45 EDT, 25 October 2023 A kill ‘switch’ which triggers the death of cancer cells...
by The Hospital for Sick Children Credit: CC0 Public DomainResearchers from The Hospital for Sick Children (SickKids), the Ontario Institute for Cancer Research (OICR) and University Health Network (UHN) have demonstrated that by analyzing patients’ blood samples, they are able to detect cancer earlier in individuals with Li-Fraumeni syndrome, an inherited condition with an almost 100%...
Published: August 3, 2023 11.01am EDT Authors Mary PhilipAssistant Professor of Medicine and Pathology, Vanderbilt University Michael RudloffMD-Ph.D. Candidate in Molecular Pathology and Immunology, Vanderbilt University This microscopy image shows a cytotoxic T cell (blue) attacking a cancer cell (green) by releasing toxic chemicals (red). Alex Ritter and Jennifer Lippincott Schwartz and Gillian Griffiths/National Institutes of...
by Nancy Fliesler, Children’s Hospital Boston Senescence inducer CuSO4, which causes ER stress, activates NKp46- and NKG2D-dependent NK killing, but 4-PBA, which induces senescence without ER stress, does not. a, Representative flow cytometry histograms of β-galactosidase activity (SA-βgal) (left) and MFI of 3 samples (right) of KP that were untreated (UT) or treated with CuSO4 or 4-PBA....
by Acoustical Society of America Attaching microbubbles to macrophages can create high-resolution and sensitive tracking images useful for disease diagnosis. Credit: Ashley Alva Macrophages, a type of white blood cell, defend the body by engulfing and digesting foreign particles, such as bacteria, viruses, and dead cells. The immune cells also tend to accumulate in solid...
by Children’s Hospital of Philadelphia Representative images from subject 3 who had both measurable and MIBG-evaluable neuroblastoma and an overall central radiology reviewed PR from cycles 3 through 8, and PD at cycle 11. This patient enrolled with a history of progressive disease on a prior irinotecan-containing regimen. The left top panel shows the baseline 3.5-cm...
by Will Cushman, University of Wisconsin-Madison Characterization of the thrombosis-mediated navigation system. (A) Schematic of the thrombosis-mediated navigation system for P-aPD-1. Truncated tissue factor–Arg-Gly-Asp (RGD) (tTF-RGD), administered either by intravenous (i.v.) or p.t. routes, targets tumor neovasculature endothelial cells and initiates coagulation cascade to recruit anti–programmed cell death 1 (PD-1) antibody–conjugated platelets (P-aPD-1). P-aPD-1 is activated...
