by Sharita Forrest, University of Illinois at Urbana-Champaign Treating breast tumors with two cancer drugs simultaneously may prevent endocrine resistance by attacking the disease along two separate gene pathways, scientists at the University of Illinois found in a new study. The two drugs used in the study, selinexor and 4-OHT, caused the cancer cells to die and tumors to regress for prolonged periods, said food science and human nutrition professor Zeynep Madak-Erdogan, the...
Tag: <span>tumors</span>
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Tumours use a metabolic twist to make lipids
To survive and divide, cancer cells need a constant supply of lipid molecules called monounsaturated fatty acids. Tumours can achieve this by an unsuspected route that harnesses a metabolic pathway also used in hair follicles. Abnormal cellular metabolism is a hallmark of cancer cells, from alterations in the pathways that use glucose to aberrant activation...
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Heating up cold tumors
NEW YORK, Jan. 22, 2019–A Ludwig Cancer Research study has uncovered a cellular mechanism by which melanomas that fail to respond to checkpoint blockade may be made susceptible to such immunotherapies. Led by Ping-Chih Ho of the Lausanne Branch of the Ludwig Institute for Cancer Research and reported in the current issue of Nature Immunology,...
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Genomic analysis is important even for ultra-hypermutated tumors prior to immune therapy
New research from The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) underscores the importance of genomic analysis of rare malignant tumors that are genetically unstable and have high numbers of gene mutations. Killer T cells surround a cancer cell. Credit: NIH OSUCCC-James investigators analyzed the cancer genomes of nine metastatic tumors and the...
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An errant editing enzyme promotes tumor suppressor loss and leukemia propagation
Writing in the January 3 issue of Cancer Cell, researchers at University of California San Diego School of Medicine report that detection of “copy editing” by a stem cell enzyme called ADAR1, which is active in more than 20 tumor types, may provide a kind of molecular radar for early detection of malignancies and represent...
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New drug seeks receptors in sarcoma cells, attacks tumors in animal trials
A new compound that targets a receptor within sarcoma cancer cells shrank tumors and hampered their ability to spread in mice and pigs, a study from researchers at the University of Illinois reports. Image: The new drug candidate, shown in green, fits precisely into the active site within the target protein, retonoid X receptor. Credit: Dipanjan Pan, University...
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New immunotherapy technique can specifically target tumor cells, UCI study reports
A new immunotherapy screening prototype developed by University of California, Irvine researchers can quickly create individualized cancer treatments that will allow physicians to effectively target tumors without the side effects of standard cancer drugs. UCI’s Weian Zhao and Nobel laureate David Baltimore with Caltech led the research team that developed a tracking and screening system...
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Virus-targeting white blood cells in tumors offer intriguing insights into responsiveness to immunotherapy
July 16, 2018, Agency for Science, Technology and Research (A*STAR), Singapore Bystander cells present in human lung and colorectal tumors could indicate how well a patient will respond to immunotherapy, an A*STAR-led study finds. Green and red tumor-infiltrating lymphocytes expressing CD39 in human lung cancer. Credit: A*STAR Singapore Immunology Network Directing patients’ immune responses against...
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New cancer immunotherapy shows promise in early tests
Much cancer immunotherapy research has focused on harnessing the immune system’s T cells to fight tumors, “but we knew that other types of immune cells could be important in fighting cancer too,” says Ashish Kulkarni at the University of Massachusetts Amherst. Now he and colleagues at Brigham and Women’s Hospital, with others, report that in preclinical models...
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Research shows possible new target for immunotherapy for solid tumors
Scanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Research from the University of Cincinnati (UC) reveals a potential new target to help T cells (white blood cells) infiltrate certain solid tumors. This study, being published in the April 24 advance online edition of...