Highlights iENPs can be converted from fibroblasts using hESC-ENP enriched factors iENPs exhibit cellular and molecular characteristics resembling hESC-ENPs iENPs induced by different TF combinations exhibit different neural propensity iENP and their neuronal derivatives recapitulated HD and AD phenotypes Summary Early human embryonic stem cell (hESC)-derived neural populations consist of various embryonic neural progenitors (ENPs)...