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The Achilles heel of the influenza virus: Ubiquitin protein may be an approach for future medicines
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The Achilles heel of the influenza virus: Ubiquitin protein may be an approach for future medicines

by Universität Münster  UB-modified lysines reside in functional domains of the IAV polymerase. a, b 3D structural models of a WSN-adapted heterotrimeric IAV polymerase bound to vRNA (adapted from PDB: 4WSB; a) or cRNA (adapted from PDB: 5EPI; b) created by comparative homology modeling. Positions of lysines with diglycyl remnants are depicted in violet (PB2,...