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Degrading modified proteins could treat Alzheimer’s, other ‘undruggable’ diseases
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Degrading modified proteins could treat Alzheimer’s, other ‘undruggable’ diseases

by American Chemical Society Graphical abstract. Credit: ACS Central Science (2023). DOI: 10.1021/acscentsci.2c01369 Certain diseases, including Alzheimer’s, are currently considered “undruggable” because traditional small molecule drugs can’t interfere with the proteins responsible for the illnesses. But a new technique that specifically targets and breaks apart certain proteins—rather than just interfering with them—may offer a pathway toward treatment....