by University of California – San Diego Head and neck cancer is one of the leading causes of cancer-related deaths worldwide, and squamous cell carcinomas (HNSCC) account for the majority of these cases. In a new study, based on preclinical research and published July 29, 2020 in Molecular Cancer Therapeutics, a journal of the American...
Tag: <span>undruggable proteins</span>
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Researchers discover new member of novel drug family for ‘undruggable’ targets
by Nicole Davis, Broad Institute of MIT and Harvard In the last several years, excitement has surged for a promising class of drugs that work not by inhibiting the action of a molecular target, as most conventional drugs do, but instead by harnessing the cell’s recycling system to destroy the target. However, these unusual compounds,...
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Cancer breakthrough: Scientists discover how to kill ‘undruggable’ proteins using ‘the kiss of death’
Many cancers and Huntington’s are caused by stubborn proteins Ras and Myc No previous studies have been able to kill the ‘undruggable’ proteins A team at the University of Dundee forced molecules to bind to Ras and Myc In doing so, they successfully destroyed them – paving the way to a cure Scientists have discovered...