Tag: <span>Urinary proteomics</span>

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Urinary proteomics identified alternation of an enzyme that consumes itaconate in the TCA cycle and implicated a role of itaconite as an immune modulating metabolite in COVID-19
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Urinary proteomics identified alternation of an enzyme that consumes itaconate in the TCA cycle and implicated a role of itaconite as an immune modulating metabolite in COVID-19

SCIENCE CHINA PRESS IMAGE: OVEREXPRESSION OF CLYBL COULD LEAD TO THE LOSS OF UPSTREAM METABOLITES, THUS RESULTING IN THE REDUCTION OF ITACONATE. ITACONATE CAN INHIBIT SUCCINATE DEHYDROGENASE (SDH), ACTIVATE NRF2/NFE2L2 VIA ALKYLATION OF KEAP1, AND INHIBIT CASPASE-1-MEDIATED CLEAVAGE OF IL-1Β AND IL-18 TO AVOID EXCESSIVE INFLAMMATION VIA THE BLOCKAGE OF NLRP3 INFLAMMASOME ACTIVATION. CREDIT: ©SCIENCE...