by Eileen Hoftyzer, University of Toronto Recent research from the Tanz Center for Research in Neurodegenerative Diseases in the University of Toronto’s Temerty Faculty of Medicine is challenging long-held views of how a hormone called somatostatin influences the earliest stages of Alzheimer’s disease. “Importantly, for the first time, this research indicates the extent to which somatostatin...
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Study shows benefit of universal genetic testing after breast cancer diagnosis
by Walter and Eliza Hall Institute of Medical Research Classification of 31 participants found to carry pathogenic gene variants, by gene, estimated risk of having a pathogenic gene variant,* and effect on treatment recommendations. Pathologic gene variants estimated with the CanRisk or Manchester algorithms. Credit: Medical Journal of Australia (2023). DOI: 10.5694/mja2.51906 According to Australian guidelines, women with...
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Combination of gene therapy and chemotherapy may provide new treatment option in bone cancer
by University College Dublin 3D render of the tibias treated with the current clinical treatment option chemotherapeutics or treated with chemotherapeutics plus gene therapy. Post-treatment there is significantly more bone (purple) present following treatment with the novel therapeutics. Credit: Created with Biorender.com. New research has identified a potential therapeutic target and developed a unique delivery system...
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AstraZeneca, Ionis unveil full PhIII data for ‘mega brand’ ATTR drug
April 24, 2023 07:00 AM EDTUpdated 09:16 AM R&DPharmaAstraZeneca, Ionis unveil full PhIII data for ‘mega brand’ ATTR drugMax GelmanSenior EditorAstraZeneca and Ionis fleshed out a Phase III win for eplontersen Monday morning at this year’s American Academy of Neurology meeting, illustrating why the pair is so confident in its potential success. Eplontersen all but...
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Omics data suggests larger effect of smoking on body mass index than previously thought
by Public Library of Science Credit: monstreh, Pixabay, CC0 (creativecommons.org/publicdomain/zero/1.0/) Smoking-related DNA methylation patterns explain around a fifth of the variation in body mass index (BMI) between individuals, according to a study publishing September 9th in the open-access journal PLOS Genetics, led by Carmen Amador at the University of Edinburgh. Amador and colleagues analyzed genomic sequence data from over...