by University of Birmingham PF4 binding to c-Mpl disrupts TPO binding. (A) AlphaFold prediction of the binding of PF4 and TPO to c-Mpl. Overlayed cartoon structures of c-Mpl (green) complexed with either PF4 (blue) or TPO (orange) as modeled using Colabfold. Structure predictions were ranked by pLDDT, a per-residue measure of the confidence of the predicted...
