by Babraham Institute Microscopy image of a germinal center structure which is altered in aged mice. Credit: Babraham Institute Understanding the ways our immune response changes as we age holds the key to designing better vaccines and boosting protection for people most at risk. Research published by Dr. Michelle Linterman and her group today in Nature Immunology has...
Tag: <span>vaccine response</span>
Research explains how our body clock influences vaccine responses
by RCSI Circadian variation in mitochondrial calcium and antigen processing is directed via control of the mitochondrial calcium uniporter. a Spleens were isolated from WT mice at ZT 1, 7, 13 and 19. CD11c+ cells were isolated and mRNA analyszd by qPCR. Circadian analysis was performed using Metacycle and cycMethod set to “JTK”. P value for each gene is specified...
Metabolic hormone ‘leptin’ linked to vaccine response
by University of Queensland Credit: Unsplash/CC0 Public Domain Reduced levels of a metabolic hormone known as leptin is linked to poor vaccine antibody responses in the general population, a University of Queensland study has found. The researchers made the discovery while investigating several cohorts’ responses to the influenza vaccine or hepatitis B vaccine pre-COVID. UQ’s Professor Di Yu...